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https://www.sciencedirect.com/science/article/pii/S016836599900228X
Mar 01, 2000 · Lectin-mediated drug delivery:: The second generation of bioadhesives ... the advantages of bioadhesive drug delivery systems were seen in their potential (i) to prolong the residence time at the site of drug absorption (e.g. in order to reduce the dosing frequency for bioadhesive controlled release formulations), and (ii) to intensify the ...Author: Claus-Michael Lehr
https://www.ncbi.nlm.nih.gov/pubmed/10699266
Mar 01, 2000 · Lectin-mediated drug delivery: the second generation of bioadhesives. ... The area of bioadhesion in drug delivery had started some 20 years ago by using so-called mucoadhesive polymers. Many of these polymers were already used as excipients in pharmaceutical formulations. This has facilitated the development of the first bioadhesive drug ...Author: Claus-Michael Lehr
https://www.researchgate.net/publication/12616924_Lectin-mediated_drug_delivery_the_second_generation_of_bioadhesives
Lectin-mediated drug delivery: the second generation of bioadhesives Article in Journal of Controlled Release 65(1-2):19-29 · April 2000 with 365 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0168365901005387
As premature inactivation by shed off mucus and the relatively fast mucus turnover limits utility of mucoadhesive excipients, lectin-mediated drug delivery was proposed as the second generation of bioadhesives . In contrast to mucoadhesives, some lectins directly adhere to carbohydrate-containing receptors at epithelial surfaces .Author: M Wirth, K Gerhardt, C Wurm, F Gabor
https://academic.oup.com/jac/article/54/4/761/763466
Oct 01, 2004 · Introduction. Bioadhesive drug delivery systems enhance drug bioavailability by prolonged residence at the site of absorption owing to increased epithelial contact. 1 Most bioadhesives known to date are synthetic macromolecules, in the form of micro/nanoparticles that interact with the mucosal surface and are hence referred to as mucoadhesives. 2 The maximum duration of adhesion of a ...Author: Anjali Sharma, Sadhna Sharma, G. K. Khuller
https://www.researchgate.net/publication/291666028_Lectin-mediated_drug_delivery_-_A_step_forward_in_development_of_bioadhesive_drug_delivery_systems
Lectin-mediated drug delivery: The second generation of. bioadhesives. J Control Release 2000; 65: 19–29. ... For the development of lectin-mediated drug delivery systems, the proteolytic ...
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