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https://www.sciencedirect.com/science/article/pii/B9780128139974000098
The chemical drug delivery system (CDS) approach refers to a combination strategy of applying prodrug and lipophilic analog designs. The CDS is defined as a prodrug approach that also uses improved lipophilicity and subsequently requires a downstream metabolic conversion step to trap the intermediate in brain tissue.Author: James Pan, Yuhao Huang, Gerald Grant
https://www.tandfonline.com/doi/abs/10.1080/107175401317245895
In this study, a novel intravascular drug delivery system was developed in which a drug injected from a catheter was fixed to the vasculature of the targeted tissue. Cellular proteins of viable endothelial cells were first biotinylated directly by biotinylation reagents, and then bound by an avidinated drug or, using avidin as a linker, a biotinylated drug.Author: Katsumi Hoya, Lee R. Guterman, Laszlo Miskolczi, Leo N. Hopkins
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/intravascular-catheters-wires-and-delivery-systems-lubricious-coatings-labeling-considerations
Medical devices such as intravascular catheters, guidewires, balloon angioplasty catheters, delivery sheaths, and implant delivery systems are commonly used during minimally invasive diagnostic and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517817/
Nov 01, 2012 · This recapitulates the concept that Dox-TSL intravascular drug release/delivery provides a venue for bioavailable drug delivery, as compared to Doxil™, where the drug remains entrapped inside the liposome after delivery, where subsequent release occurs over days to weeks.Author: Ashley A. Manzoor, Lars H. Lindner, Chelsea D. Landon, Ji-Young Park, Andrew J. Simnick, Matthew R. ...
http://www.thermosome.com/
What we do Thermosome is developing drug candidates leveraging its proprietary drug delivery technology, which exploits a novel Mechanism of Action called intravascular drug release. It is our goal to utilize our proprietary platform technology and know-how for the development of improved therapeutics that create significant value to patients.
https://dspace.mit.edu/handle/1721.1/98152
An integrated model for intravascular drug delivery from a PLGA-coated DES is developed in the last part of the dissertation. The integrated model describes the processes of drug release in a PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall.
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