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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220785/
Dec 10, 2011 · Intravaginal (ivag) delivery, which is a proven way to confer local protection against STD’s contracted via the reproductive tract, is complicated by the mucus gel barrier, the hormone cycle, and the harsh mucosal environment, which leads to low residence-time for administered agents.Author: Yen Cu, Carmen J. Booth, W. Mark Saltzman
https://www.ncbi.nlm.nih.gov/pubmed/27093291/
Apr 19, 2016 · Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome. Verstraelen H(1), Vervaet C(2), Remon JP(2).Author: Hans Verstraelen, Chris Vervaet, Jean Paul Remon
https://patents.google.com/patent/WO2002076426A3/en
WO2002076426A3 PCT/IE2002/000040 IE0200040W WO02076426A3 WO 2002076426 A3 WO2002076426 A3 WO 2002076426A3 IE 0200040 W IE0200040 W IE 0200040W WO 02076426 A3 WO02076426 A3 WO 02076426A3 Authority WO WIPO (PCT) Prior art keywords drug delivery antimicrobial agent administration delivery devices intravaginal drug Prior art dateAuthor: Karl Malcolm, David Woolfson, Grant Elliott, Martin Shephard
https://www.liebertpub.com/doi/10.1089/jwh.2004.13.834
Among the delivery systems proposed for this route is the use of intravaginal gels, which have been found to be potential vaginal drug delivery systems. The bioadhesives used in the formulation of gels play a key role in the release of the drug through the attachment to the vaginal mucosa, where the drug diffuses from the gel to the mucus.Author: Mary Justin-temu, Festo Damian, Renaat Kinget, Guy Van Den Mooter
https://en.wikipedia.org/wiki/Intravaginal_administration
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration. ...
https://patents.google.com/patent/RU2591786C2/en
FIELD: medicine. SUBSTANCE: group of inventions can be used for intravaginal delivery of lubricants. Intravaginal devices include a first segment comprising an outer surface and a lumen containing an aqueous lubricant, wherein first segment is configured to deliver contents of lumen to outer surface, and first segment comprises a hydrophilic semipermeable elastomer.Author: Patrick F. Kiser, R. Tyler McCabe, Margaret N. Kiser, Theodore Henry Albright
https://www.sciencedirect.com/science/article/pii/S0168365917310611
Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging route of administration, due to the clearance mechanisms present which result in poor retention of dosage forms, and the potential for irritation and other adverse reactions.Author: Michael T. Cook, Marc B. Brown
https://www.hindawi.com/journals/bmri/2018/3714329/
The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvovaginal candidiasis (VVC).Author: Franklin Chimaobi Kenechukwu, Anthony Amaechi Attama, Emmanuel Chinedum Ibezim, Petra Obioma Nnamani...
https://www.drugs.com/cg/vaginal-delivery.html
Feb 03, 2020 · What do I need to know about vaginal delivery? A vaginal delivery occurs when your baby is born through your vagina (birth canal). How do I prepare for vaginal delivery? You can ask someone to be with you during labor and delivery. The person can be a spouse, friend, or family member. This person can help make you more comfortable.
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