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https://www.rxlist.com/mirena-drug.htm
Oct 24, 2018 · Low doses of LNG are administered into the uterine cavity with the Mirena intrauterine delivery system. The initial release rate is approximately 20 mcg/day over the first 3 months tested (day 0 to day 90). It is reduced to approximately 18 mcg/day after 1 year and then decreases progressively to approximately 10 mcg/day after 5 years.
http://www.authorstream.com/Presentation/danish_kurien-784835-intrauterine-drug-delivery-system-2/
Jan 20, 2011 · INTRAUTERINE DRUG DELIVERY SYSTEM - authorSTREAM Presentation. Wall of uterus : Wall of uterus Endometrium – inner coat of uterine wall made up of simple columnar epithelium, areolar connective tissue & endometrial glands.
https://www.ncbi.nlm.nih.gov/pubmed/20217534/
This chapter describes the development of new intrauterine drug delivery products, which are designed to provide improved methods for the prevention and treatment of gynaecological conditions, improvements to birth control methods, and higher levels of safety, user …Author: Dirk Wildemeersch
https://www.slideshare.net/PRASHANTDEORE1/intrauterine-intravaginal-drug-delivery-system
Mar 07, 2015 · Intrauterine & Intravaginal Drug Delivery System 1. PRESENTED BY DEORE PRASHANT ASHOK Department of Pharmaceutics M. Pharm. II Semester (2014-2015) Intrauterine & Intravaginal Drug Delivery System R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur . 1 [email protected] Mo.09881261646 3-Mar-15
https://www.ncbi.nlm.nih.gov/pubmed/11518454
OBJECTIVE: To evaluate the effect on menstrual blood loss of a novel 'frameless' intrauterine drug delivery system, the FibroPlant levonorgestrel intrauterine system (IUS), releasing 14 microg of levonorgestrel/day. An ancillary objective was to evaluate the contraceptive performance.Author: D Wildemeersch, Etienne Schacht
http://www.authorstream.com/Presentation/tubaaah-2522532-introduction-novel-drug-delivery-system/
Jun 16, 2015 · Intrauterine Progesterone Drug Delivery System The Progestasert System slowly releases an average of 60 mg of progesterone per day for 1 year after insertion . The Progestasert provides contraception without the need for daily self-medication The unit contains 10 mg of dinoprostone in 236 mg of a crosslinked polyethylene oxide–urethane ...
https://en.wikipedia.org/wiki/IntraUterine_System
Levonorgestrel is a progestogen, i.e. progesterone-receptor agonist. The hormonal IUD's primary mechanism of action is to prevent fertilization. The levonorgestrel intrauterine system has several contraceptive effects: The inside of the uterus becomes fatal to sperm; Cervical mucus thickensFirst use: 1990 (Mirena—currently available), 1976 (Progestasert—discontinued in 2001)
https://academic.oup.com/humupd/article/14/3/197/683294
Overall, the TCu380A was more effective than alternative devices, including the Multiload 375 (MLCu375), Multiload 250 (MLCu250), Copper T220 (TCu220) and Copper T200 (TCu200). In two studies that compared copper devices and the levonorgestrel intrauterine system (LNG-IUS), pregnancy rates were lower with the LNG-IUS than with copper devices.
https://www.sciencedirect.com/science/article/pii/S0169409X09001446
The development and release of the levonorgestrel intrauterine system (LNG IUS, Mirena ®) represents one very successful example of novel drug delivery within the contraceptive arena. In addition to its primary indication, the non-contraceptive benefits of this system will propel its use beyond the contracepting population.Author: Susan Rose, Angela Chaudhari, C. Matthew Peterson
https://www.slideshare.net/murari33pavna/intra-uterine-devices
Mar 20, 2012 · b)Bio-degradable matrix device: This drug delivery system is designed to eliminate the need for retrieving at the end of treatment it can be prepared by dissolving such a poly lactic acid, in a common organic solvent to dryness, to produce drug dispersing biodegradable matrix devices of varying shapes and sizes, The rate of drug-release from ...
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