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https://www.liebertpub.com/doi/10.1089/jwh.2004.13.834
Among the delivery systems proposed for this route is the use of intravaginal gels, which have been found to be potential vaginal drug delivery systems. The bioadhesives used in the formulation of gels play a key role in the release of the drug through the attachment to the vaginal mucosa, where the drug diffuses from the gel to the mucus.Author: Mary Justin-temu, Festo Damian, Renaat Kinget, Guy Van Den Mooter
https://en.wikipedia.org/wiki/Intravaginal_administration
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration. ...
https://www.ncbi.nlm.nih.gov/pubmed/27093291/
Apr 19, 2016 · Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome. Verstraelen H(1), Vervaet C(2), Remon JP(2).Author: Hans Verstraelen, Chris Vervaet, Jean Paul Remon
https://patents.google.com/patent/WO2002076426A3/en
An intravginal antimicrobial drug delivery device is disclosed having an antimicrobial agent dispersed throughout a biocompatible elastomeric system. Also disclosed is a method of making the antimicrobial drug delivery device.Author: Karl Malcolm, David Woolfson, Grant Elliott, Martin Shephard
https://www.tandfonline.com/doi/abs/10.3109/03639049209046329
Apr 27, 2012 · (1992). Intravaginal drug delivery. Drug Development and Industrial Pharmacy: Vol. 18, No. 11-12, pp. 1225-1279.Author: Arati A. Deshpande, C. T. Rhodes, Michele Danish
https://www.researchgate.net/publication/221875696_A_review_on_vaginal_drug_delivery_systems
A REVIEW ON VAGINAL DRUG DELIVERY SYSTEMS . KRISHNA SV, ASHOK V AND CHATTERJEE A* . Department of Pharmaceutics, Nalanda College of Pharmacy . ... Intravaginal delivery of cholera .
http://www.imedpub.com/articles/intra-vaginal-drug-delivery-systeman-overview.pdf
Advantages of intra vaginal drug delivery system Prolonged release, Minimal systemic side effects, An increase in bioavailability, Use of less total drug than an oral dose, First-pass metabolism can be avoided, Self medication is possible. Contact with digestive fluid is avoided and degradation of drug is minimized 3.Author: Chinmaya Keshari Sahoo, Prakash Kumar Nayak, Deepak Kumar Sarangi, Tanmaya Keshari Sahoo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976928/
The first intravaginal controlled drug delivery system was developed in 1970, using a vaginal ring for the delivery of medroxyprogesterone acetate for contraception . However, tablets, creams, and suppositories are now the most conventional formulations in vaginal drug delivery while vaginal rings are more commonly employed for long-term drug ...Author: Valence M. K. Ndesendo, Viness Pillay, Yahya E. Choonara, Eckhart Buchmann, David N. Bayever, Leith ...
https://www.sciencedirect.com/science/article/pii/S0168365917310611
Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging route of administration, due to the clearance mechanisms present which result in poor retention of dosage forms, and the potential for irritation and other adverse reactions.Author: Michael T. Cook, Marc B. Brown
https://www.slideshare.net/PRASHANTDEORE1/intrauterine-intravaginal-drug-delivery-system
Mar 07, 2015 · Intrauterine & Intravaginal Drug Delivery System 1. PRESENTED BY DEORE PRASHANT ASHOK Department of Pharmaceutics M. Pharm. II Semester (2014-2015) Intrauterine & Intravaginal Drug Delivery System R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur . 1 [email protected] Mo.09881261646 3-Mar-15
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