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https://www.sciencedirect.com/science/article/pii/S0012369219344484
Intratracheal delivery is an attractive approach to overcome these issues as it improves bioavailability and stability of particles or drugs in targeted lung lesions. Thus, nano- and microparticle delivery via the intratracheal route is increasingly being used in the treatment of these infectious diseases.Author: Hongbin Wang, Lina Wu, Xilin Sun
https://www.sciencedirect.com/science/article/abs/pii/S0012369219344484
Intratracheal delivery is an innovative, noninvasive approach for imaging and treating respiratory disease efficiently, when compared with other delivery methods. Intratracheal delivery of nano- and microparticles and hyperpolarized gases offers valuable clinical advantages, such as assessing lung function, monitoring ventilation and perfusion ...Author: Hongbin Wang, Lina Wu, Xilin Sun
https://www.ncbi.nlm.nih.gov/pubmed/25416381
Jan 15, 2015 · Efficient intratracheal delivery of airway epithelial cells in mice and pigs. Gui L, Qian H, Rocco KA, Grecu L, Niklason LE. Cellular therapy via direct intratracheal delivery has gained interest as a novel therapeutic strategy for treating various pulmonary diseases including cystic fibrosis lung disease.Author: Liqiong Gui, Hong Qian, Kevin A. Rocco, Loreta Grecu, Laura E. Niklason
https://medical-dictionary.thefreedictionary.com/intratracheal
The intratracheal injection of bleomycin led to the extensive proliferation of fibroblasts, the infiltration of inflammatory cells, the prominent deposition of fibrillar collagen, and the destruction of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019268/
May 03, 2016 · The present study is the first to report feasibility of AAV1 gene delivery to the distal pulmonary vessels in a large animal model using an intratracheal sprayer device. A previous report showed the advantages of such a device to deliver AAV vectors to the distal airway compared to oral nebulization or direct catheter instillation.Author: Jaume Aguero, Jaume Aguero, Kiyotake Ishikawa, Lahouaria Hadri, Carlos G. Santos-Gallego, Kenneth M....
https://journal.chestnet.org/article/S0012-3692(19)34448-4/pdf
intratracheal delivery of imaging agents and therapeutic drugs. Intratracheal delivery, or inhalation, has made great progress since it was first used to deliver medications to the lungs more than 2,000 years ago.4 A number of nano- and microparticle formulations and
http://www.onlinejacc.org/content/67/17/2032
May 03, 2016 · Results Transduction efficacy after intratracheal delivery of AAV1 was confirmed by β-galactosidase detection in the distal pulmonary vasculature. Treatment with aerosolized AAV1.SERCA2a prevented disease progression as evaluated by mean pulmonary artery pressure, vascular resistance, and limited vascular remodeling quantified by histology.Author: Jaume Aguero, Jaume Aguero, Kiyotake Ishikawa, Lahouaria Hadri, Carlos G. Santos-Gallego, Kenneth M....
https://www.jove.com/video/52261/intubation-mediated-intratracheal-imit-instillation-noninvasive-lung
For these reasons, it would be advantageous to develop a technique to instill bacteria directly into the mouse lungs in order to study LRT disease in the absence of involvement of the URT. We have termed this lung specific delivery technique intubation-mediated intratracheal (IMIT) instillation.Author: Matthew B Lawrenz, Ramy A. Fodah, Maria G. Gutierrez, Jonathan Warawa
http://rc.rcjournal.com/content/61/8/1008
Aug 01, 2016 · BACKGROUND: Intratracheal antibiotic administration is increasingly used for treating respiratory infections. Limited information is available on delivery devices, techniques, and safety. METHODS: An online survey on intratracheal administration of anti-infective agents in mechanically ventilated adults was answered by health-care workers from 192 ICUs to assess the most commonly …Author: Candela Solé-Lleonart, Jean-Jacques Rouby, Jean Chastre, Garyfallia Poulakou, Lucy B Palmer, Stijn B...
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