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https://www.nature.com/articles/nb.1866
Jun 07, 2011 · Intranasal delivery to the brain. To date, the majority of studies investigating this delivery mechanism have looked only at animal models 11, but both short- …Author: Robert I Henkin
http://intranasal.net/Peer%20Reviewed%20literature/Talegaonkar,%20Intranasal%20delivery%20-%20An%20approach%20to%20bypass%20the%20blood%20brain%20barrier,%20I%20J%20Pharm%202004.pdf
Intranasal delivery: An approach to bypass the blood brain barrier S. Talegaonkar, P. R. Mishra ABSTRACT The blood brain barrier (BBB) represents one of the strictest barriers of in vivo therapeutic drug delivery. The barrier is defined by restricted exchange of hydrophilic compounds, small proteins
http://intranasal.net/Overview/default.htm
Intranasal medication delivery - brief overview of the concept. Disclaimer: The information on this web site is for educational and informational purposes only. It is not professional medical advice nor is it intended to substitute for such.
https://www.businesswire.com/news/home/20190813005289/en/Global-Intranasal-Drug-Delivery-Market-Report-2019
Aug 13, 2019 · Global Intranasal Drug Delivery Market Report 2019: Analysis, Trends, and Forecasts 2016-2024 - Focus on Allergic Infections, Analgesics, Osteoporosis, Vaccinations - ResearchAndMarkets.com
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic ...
https://www.youtube.com/watch?v=q6uCIgWQkwM
Feb 06, 2017 · Direct transport of drug through nose to brain by passing BBB. Skip navigation ... Intranasal (nose to brain) drug delivery system Sagar Savale. ... Intranasal spray administration on mice ...Author: Sagar Savale
https://www.future-science.com/doi/full/10.4155/tde-2018-0002
The central premises behind intranasal delivery rest on careful study of nasal cavity physiology and a body of animal research that has examined the transport of other peptide molecules. Almost every human oxytocin administration study of behavior or cognition has used the intranasal route for delivery to the brain.
http://www.ajnmmi.us/files/ajnmmi0108227.pdf
Intranasal (IN) delivery is a promising alterna-tive to systemic administration that uses the direct anatomic pathway between the olfacto-ry/trigeminal neuroepithelium of the nasal mucosa and the brain. Since only small amounts of a drug are delivered to the brain using this route, the mechanism of delivery
https://journals.lww.com/neurotodayonline/pages/articleviewer.aspx?year=2009&issue=08030&article=00002&type=Fulltext
In collaboration with Dr. Frey, Dr. Reyes said that he is now designing studies to test the benefits of intranasal delivery of medications to the brain for treating AD, Parkinson disease, and gliomas. “This opens up a whole new pathway for drug delivery,” Dr. Reyes said.
https://www.jove.com/video/58485/novel-methods-for-intranasal-administration-under-inhalation
Intranasal administration has been reported to be a potential pathway for nose-to-brain delivery of therapeutic agents that circumvents the blood-brain barrier. However, there have been few reports regarding not only the quantitative analysis but also optimal administration conditions and dosing regimens for investigations of nose-to-brain ...
http://cbcrp.org.200.seekdotnet.com/research/PageGrant.asp?grant_id=23508
As well, we will now pursue drug delivery via intranasal administration, in an effort to increase therapeutic outcome even further. Intranasal delivery may support direct brain entry of the drug, which may lead to further concentrated anticancer activity against those difficult-to-treat breast brain metastases. Progress Report 2 (2015)
https://link.springer.com/chapter/10.1007%2F978-3-030-16715-8_10
One of the major problems is the blood–brain barrier (BBB), which hampers drug delivery into the brain. Intranasal (IN) route will overcome this obstacle by delivering drugs or cells directly to the central nervous system (CNS) through the olfactory and trigeminal neural pathways.
https://www.nature.com/articles/srep28599
Jun 27, 2016 · Brain drug delivery for the treatment of a wide variety of central nervous system (CNS) diseases is hampered by the blood-brain barrier (BBB) 1.Intranasal (IN) brain drug delivery is …
https://en.wikipedia.org/wiki/Nanoparticles_for_drug_delivery_to_the_brain
Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood–brain barrier (BBB) using nanoparticles.These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders.
https://www.hindawi.com/journals/jphar/2013/812387/
The results indicate that 0.5 mg/kg of siRNA is delivered successfully to the hippocampus, thalamus, hypothalamus, and Purkinje cells in the cerebellum after 4 hrs of post intranasal delivery. The results indicate maximum delivery to the brain in comparison to other tissues with no cellular toxic effects.
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