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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
https://www.ncbi.nlm.nih.gov/pubmed/29277310
Feb 15, 2018 · The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves. The purpose of this review is to describe the details of this mechanism to better direct future research.Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
https://www.nature.com/articles/nb.1866
Jun 07, 2011 · Intranasal drug administration has also been used to deliver peptide hormones to regulate enuresis 6 and renal colic 7. Several factors are thought to influence drug uptake into the brain …Author: Robert I Henkin
https://www.sciencedirect.com/science/article/pii/S0378517319303862
Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs into the CNS at a higher rate and extent than other conventional routes. The mechanism of drug transport from nose-to-brain is not fully understood yet, but several neuronal pathways are considered to be involved.Author: Bappaditya Chatterjee, Bapi Gorain, Keithanchali Mohananaidu, Pinaki Sengupta, Uttam Kumar Mandal, H...
https://www.sciencedirect.com/science/article/pii/S0361923018303678
The intranasal drugs can bypass the blood-brain barrier and blood-CSF barrier. There are in vitro, ex vivo and in vivo models for testing drug penetration by intranasal route. The drug penetartion from nasal cavity can be enhanced by various formulations and devices. Transporter modulation can also help in nasal delivery of their substrates.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.nature.com/articles/srep41768
Jan 31, 2017 · Intranasal delivery of neuroprotective ST266 is a potential novel, noninvasive therapeutic modality for the eyes, optic nerves and brain.Author: Reas S. Khan, Kimberly Dine, Bailey Bauman, Michael Lorentsen, Lisa Lin, Helayna Brown, Leah R. Hans...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · In contrast, nose-to-brain delivery is a minimally invasive drug administration pathway, which bypasses the blood-brain barrier as the drug is directed from the nasal cavity to the brain. In particular, the skull base located at the roof of the nasal cavity is in close vicinity to the CNS.Author: Stella Gänger, Katharina Schindowski
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184840/
Oct 03, 2014 · Intranasal (IN) administration is a promising approach for drug delivery to the brain, bypassing the BBB; however, its application has been restricted to particularly potent substances and it does not offer localized delivery to specific brain sites.Author: Hong Chen, Cherry C. Chen, Camilo Acosta, Shih-Ying Wu, Tao Sun, Elisa E. Konofagou
http://intranasal.net/Overview/default.htm
IN administration may rapidly achieve therapeutic brain and spinal cord (CNS) drug concentrations. Indications for intranasal medication delivery. Intranasal (IN) medication delivery is simply another option or method to deliver therapeutic medications to the …
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