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http://intranasal.net/Overview/default.htm
Intranasal (IN) medication delivery is simply another option or method to deliver therapeutic medications to the patient’s blood stream to achieve a desired clinical effect. It is a tool in the therapeutic armamentarium just as oral, rectal, sublingual, intramuscular and intravenous delivery methods are also tools to deliver medications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
http://intranasal.net/DeliveryTechniques/default.htm
Sprayed or atomized medication delivery. Sprayed or atomized intranasal medication delivery is a more recent technique adopted by the pharmaceutical industry due to improved usability issues as well as improved bioavailability data.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · Intranasal CNS Delivery and Some Clinical Evidences of Its Applicability. In general, the nasal cavity is highly suitable for drug delivery as the nasal mucosa presents an efficient absorption and a very good permeability of both: small molecule drugs and biopharmaceuticals. Furthermore, the roof of the nasal cavity is located in very close ...Author: Stella Gänger, Katharina Schindowski
https://www.sciencedirect.com/science/article/pii/S0361923018303678
Although the BBB has the ability to transport leptin into the CNS from the blood, this transport is impaired during obesity (Banks et al., 1999), making intranasal delivery of leptin into the CNS a potential strategy to regulate feeding behavior.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Particulate delivery systems are proven efficient carriers for vaccine delivery , and the most frequently used systems are lipoplex , and liposomes , , , . While these lipid-based nano carriers can deliver mRNA efficiently, the epithelial barrier remains a challenge to intranasal delivery of mRNA vaccines.Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
http://med.umkc.edu/docs/em/IN_Med_dosing_chart.pdf
Intranasal medications and doses based on published literature Clinical Scenario Intranasal Medication and dose Important reminders Pain control Fentanyl 2.0 ug/kg Ketamine 0.5 to 1 mg/kg •Always monitor for respiratory depression • Only use a device that can …File Size: 87KB
https://www.jove.com/video/55845/intranasal-delivery-therapeutic-stem-cells-to-glioblastoma-mouse
Stem cells are promising therapeutic carriers to treat brain tumors due to their intrinsic tumor tropism. Non-invasive intranasal stem cell delivery bypasses the blood brain barrier and demonstrates strong potential for clinical translation. …Author: Dou Yu, Gina Li, Maciej S. Lesniak, Irina V. Balyasnikova
http://www.biopharminternational.com/innovations-intranasal-vaccine-delivery-technology
Oct 01, 2009 · Innovative delivery technologies for the needle-free delivery of vaccines by the intranasal route offer advantages to traditional parenteral needle-based delivery systems developed and produced by the vaccine industry. Dry powder intranasal vaccine technologies have recently been developed.
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