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https://advances.sciencemag.org/content/6/5/eaax4690.full
Jan 01, 2020 · CCR9+ T cells have an increased potential to be activated and therefore may mediate strong antitumor responses. Here, we found, however, that CCL25, the only chemokine for CCR9+ cells, is not expressed in human or murine triple-negative breast cancers (TNBCs), raising a hypothesis that intratumoral delivery of CCL25 may enhance antitumor immunotherapy in TNBCs. We first …Author: Hongmei Chen, Xiuxiu Cong, Chenxi Wu, Xuan Wu, Jialiang Wang, Jialiang Wang, Kuirong Mao, Kuirong Ma...
https://drug-dev.com/intratumoral-delivery-combining-local-systemic-treatments-could-immuno-oncology-finally-enable-local-intratumoral-delivery/
These programs include intratumoral delivery of RIG-1, STING, and TLR9. 16-18. Though the idea for intratumoral delivery to provide inflammation and antigen release is intriguing, these agents still need to be absorbed, retained, and dispersed in the tumor to be effective. Chemical compatibility between the drug formulation and the tumor is ...
https://cancerimmunolres.aacrjournals.org/content/early/2020/03/03/2326-6066.CIR-19-0628
Jan 01, 2020 · Intratumoral Delivery of a PD-1-blocking scFv encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade. Chaolong Lin, Wenfeng Ren, Yong Luo, Shaopeng Li, Yating Chang, Lu Li, Dan Xiong, Xiaoxuan Huang, Zilong Xu, Zeng Yu, Yingbin Wang, Jun Zhang, Chenghao Huang and Ningshao Xia.Author: Chaolong Lin, Wenfeng Ren, Yong Luo, Shaopeng Li, Yating Chang, Lu Li, Dan Xiong, Xiaoxuan Huang, Zi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131473/
By comparing the compositions and structures of the tumors, the authors concluded that the resistance to macromolecule penetration was due to the difference in collagen organization rather than the hyaluronan or total GAG content, suggesting that it is the collagen network that should primarily be addressed for efficient intratumoral delivery ...Author: Hillary Holback, Yoon Yeo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690785/
Apr 21, 2009 · Direct intratumoral delivery systems have significant potential advantages due to providing higher drug concentration at the target site compared with systemic routes and circumvention of the various physiological barriers to tumor drug delivery including the high interstitial pressure common to most solid tumors .Author: Abeer M. Al-Ghananeem, Ahmad H. Malkawi, Yahya M. Muammer, Justin M. Balko, Esther P. Black, Walid M...
https://cancerimmunolres.aacrjournals.org/content/4/2/146
Feb 01, 2016 · Intratumoral delivery of TriMix eliminates the challenge of trying to define the best-suited TAA for vaccination. In this regard, cancer-testis and differentiation antigens are often used. These are self-proteins and are thus subjected to tolerance mechanisms.Author: Sandra Van Lint, Dries Renmans, Katleen Broos, Lode Goethals, Sarah Maenhout, Daphné Benteyn, Cleo G...
https://www.researchgate.net/publication/312126616_Intratumoral_Delivery_of_Immunotherapy-Act_Locally_Think_Globally
Intratumoral delivery of viruses and virus-associated molecular patterns can achieve antitumor effects that are largely mediated by the elicitation or potentiation of immune responses against the ...
https://drug-dev.com/intratumoral-delivery-arming-the-immune-system-turning-cold-tumors-hot/
INTRATUMORAL DELIVERY – Arming the Immune System; Turning Cold Tumors Hot. INTRODUCTION. Finding a cure for cancer has been the foremost goals of researchers for decades. It’s like archeologists searching for the Holy Grail or the lost city of Atlantis. Only today, science continues to make progress in this fight, exploring a variety of ...
https://clincancerres.aacrjournals.org/content/26/3/598
Feb 01, 2020 · Purpose: IL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic administration leads to severe adverse events (AE), including death. This pilot trial investigated safety, efficacy, and immunologic activity of intratumoral delivery of IL12 plasmid DNA (tavo) via in vivo electroporation (i.t.-tavo-EP) in patients with Merkel cell carcinoma (MCC), an ...Author: Shailender Bhatia, Shailender Bhatia, Natalie V. Longino, Natalie J Miller, Rima M Kulikauskas, Jaya...
https://www.annalsofoncology.org/article/S0923-7534(20)35925-1/fulltext
Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients. A. Algazi. x. A. Algazi. Search for articles by this author Affiliations. Department of Medicine, University of California, San Francisco, San Francisco, USA; 1, S. Bhatia. x.
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