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https://www.medtronic.com/us-en/patients/treatments-therapies/drug-pump-chronic-pain.html
OVERVIEW TARGETED DRUG DELIVERY. Patients report a reduction in pain scores after receiving targeted drug delivery. 51% of patients completely eliminated other opioids* at 12 months. 1; 87% of patients rated their quality of life as fair to excellent. 2; 90% of patients would recommend therapy to a family member or friend. 2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761861/
Jan 29, 2016 · Intrathecal infusions of analgesics have been used for more than 20 years to treat chronic pain that is refractory to conventional therapies. 2 Implanted programmable pumps have been available in Canada since 1991. 3 An intrathecal drug delivery system is, therefore, one option for treating refractory nonmalignant pain. Intrathecal drug delivery systems are provided for chronic refractory nonmalignant and malignant pain …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964247/
Intrathecal drug delivery (ITDD) systems are an option for the management of patients with chronic non-cancer pain, cancer pain and spasticity. Concerns over their invasiveness and high initial costs have led National Health Service (NHS) England to decommission ITDD for patients with chronic non-cancer pain.Author: Rui V Duarte, Tosin Lambe, Jon H Raphael, Jon H Raphael, Sam Eldabe, Lazaros Andronis, Lazaros Andro...
https://touchneurology.com/intrathecal-drug-delivery-for-neuropathic-pain/
Midazolam is currently a fourth-line intrathecal treatment for chronic pain. 28 Spinal GABA and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been implicated in the mechanisms of neuropathic pain after nerve injury.
https://www.webmd.com/pain-management/guide/spinal-drug-delivery-systems
Pain relief through spinal drug delivery systems, also called intrathecal drug delivery systems, involves implanting a small pump or using a catheter that delivers medication directly to the spinal...
https://www.asra.com/page/223/intrathecal-dosing-and-medication-selection
The current intrathecal drug delivery systems (IDDS) are approved by the Food and Drug Administration (FDA) for administration of a single agent and there are only 3 FDA approved agents: baclofen for spasticity and morphine and ziconotide for pain.
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