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https://pubs.rsc.org/en/content/articlelanding/2011/py/c0py00324g
There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This nAuthor: Christopher A. Blencowe, Andrew T. Russell, Francesca Greco, Wayne Hayes, David W. Thornthwaite
https://pubs.rsc.org/en/content/articlehtml/2011/py/c0py00324g
Recent reviews have discussed self-immolative linkers for tumour-activated prodrug therapies and biological conjugates, 14–17 herein we systematically review the mechanistic aspects of self immolative technology focussing on their use in macromolecular systems. Classical self-immolative linkers combine a protecting group with a single reporter moiety, whereby a single activation event leads to …Author: Christopher A. Blencowe, Andrew T. Russell, Francesca Greco, Wayne Hayes, David W. Thornthwaite
https://www.researchgate.net/publication/255750394_Self-immolative_linkers_in_polymeric_delivery_systems
The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups,...
https://core.ac.uk/download/pdf/9101.pdf
self-immolative linker technology has led to self immolative systems capable of amplified release (Scheme 1c). In this case a single activation event leads to the release of multiple reporter groups.18-20 More recently, systems capable of 60 relayed amplified release whereby a single activation event
https://www.semanticscholar.org/paper/Self-immolative-linkers-in-polymeric-delivery-Blencowe-Russell/8b954934a330855229e9e544d6fd891614f963f3
The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer.
http://centaur.reading.ac.uk/16420/
The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682828/
Jul 28, 2011 · The use of self-immolative linkers has become increasingly popular in drug development, molecular sensors, and polymeric delivery systems. Linkers that undergo self-immolative elimination upon removal of the protecting group can release an active species through a 1,6-benzyl elimination …Author: Jody L. Major Jourden, Kevin B. Daniel, Seth M. Cohen
https://link.springer.com/article/10.1007/s12274-018-2134-5
Jul 11, 2018 · Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery. To covalently connect the polymer and drug, disulfide-bearing linkers, such as 3,3’-dithiodipropionic acid (DDPA) and 4,4’-dithiodibutyric acid (DDBA), are used.Author: Xuan Meng, Min Gao, Jian Deng, Di Lu, Aiping Fan, Dan Ding, Deling Kong, Zheng Wang, Yanjun Zhao
https://www.sciencedirect.com/science/article/pii/S1385894717322209
In general, Self-Immolative Polymers (SIPs) are produced through a polymerization reaction of the appropriate monomer to then cap the terminal head-group of the polymer with a specific protecting group, leading to a polymer with a trigger.Author: M. Gisbert-Garzarán, M. Gisbert-Garzarán, M. Manzano, M. Manzano, M. Vallet-Regí, M. Vallet-Regí
https://core.ac.uk/display/9101
The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer.
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