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https://www.neuromodulation.com/pump
In intrathecal drug delivery, pain medications and/or medications used for spasticity are introduced directly to the spinal fluid (intrathecal space) through a drug delivery system comprised of a pump and catheter. The intrathecal space is usually accessed from the lumbar region of the lower back.
https://www.spineorthocenter.com/services/pain-management/intraspinal-drug-delivery-systems/
Intraspinal Drug Delivery Systems Many medications that are normally given orally or intravenously can be delivered directly into the spinal canal. The advantage of this delivery is that a much smaller dosages of medication can be used, thereby minimizing many side effects associated with other oral or intravenous use.Typically, the intraspinal administration is 300 times more effective than the oral dose.
https://millenniumpaincenter.com/procedures/procedure/intraspinal-drug-delivery-systems
Procedures / Intraspinal Drug Delivery Systems Many medications that are normally given orally or intravenously can be delivered directly into the spinal canal. The advantage of this delivery is that a much smaller dosages of medication can be used, thereby minimizing many side effects associated with other oral or intravenous use.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817765/
Apr 21, 2015 · Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury Florentia Papastefanaki , 1 Igor Jakovcevski , 2, 3, 4 Nafsika Poulia , 1 Nevena Djogo , 2 Florian Schulz , 5 Tamara Martinovic , 6 Darko Ciric , 6 Gabrielle Loers , 2 Tobias Vossmeyer , 5 Horst Weller , 5, 7 Melitta ...Author: Florentia Papastefanaki, Igor Jakovcevski, Igor Jakovcevski, Nafsika Poulia, Nevena Djogo, Florian S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892916/
Jul 28, 2014 · Intrathecal drug delivery is an effective pain management option for patients with chronic and cancer pain. The delivery of drugs into the intrathecal space provides superior analgesia with smaller doses of analgesics to minimize side effects while significantly improving quality of life.Author: Gaurav Bhatia, Mary E Lau, Katharine M Koury, Padma Gulur
https://www.asra.com/page/223/intrathecal-dosing-and-medication-selection
However, it is not unusual for intrathecal medication and dosing to evolve with time after implant. The current intrathecal drug delivery systems (IDDS) are approved by the Food and Drug Administration (FDA) for administration of a single agent and there are only 3 FDA approved agents: baclofen for spasticity and morphine and ziconotide for pain.
https://www.sciencedirect.com/science/article/pii/S0169409X20300120
The potential significance of IT drug delivery for the treatment of CNS disease is amplified by deepened understanding of dynamic exchange between CSF, interstitial fluid (ISF), and peripheral tissue sites, which provides an opportunity to alter the distribution of nanomedicine through fluid convection . It is thus not surprising that IT delivery of nanoparticles has found utility in a multitude of preclinical models of …Author: M.J. Fowler, J.D. Cotter, B.E. Knight, E.M. Sevick-Muraca, D.I. Sandberg, D.I. Sandberg, R.W. Sirian...
https://www.researchgate.net/publication/268282377_Current_perspectives_on_intrathecal_drug_delivery
Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug...
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1525-1403.2012.00476.x
Introduction: The use of intrathecal (IT) infusion of analgesic medications to treat patients with chronic refractory pain has increased since its inception in the 1980s, and the need for clinical research in IT therapy is ongoing. The Polyanalgesic Consensus Conference (PACC) panel of experts convened in 2000, 2003, and 2007 to make recommendations on the rational use of IT analgesics based ...Author: Timothy R. Deer, Joshua Prager, Robert Levy, James Rathmell, Eric Buchser, Allen Burton, David Caraw...
https://basicmedicalkey.com/intraspinal-analgesia-epidural-and-intrathecal/
Delivery of Intraspinal Analgesics. Delivery of analgesics by the intraspinal routes can be accomplished by inserting a needle into the subarachnoid space (for intrathecal analgesia) or the epidural space and injecting the analgesic, or threading a catheter through the needle and taping it in place temporarily for bolus dosing or continuous administration (Figures 15-4 to 15-6). Temporary catheters …
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