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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900774/
Intrascleral delivery of nanoparticles and microparticles presents the opportunity for controlled release drug delivery over extended periods of time. In this scenario, drug-loaded particles could be injected into the sclera, where they form a slow-release depot for delivery into the eye.Author: Jason Jiang, Jason S. Moore, Henry F. Edelhauser, Mark R. Prausnitz
https://www.researchgate.net/publication/23446611_Intrascleral_Drug_Delivery_to_the_Eye_Using_Hollow_Microneedles
Intrascleral Drug Delivery to the Eye Using Hollow Microneedles ... via intracorneal or intrascleral routes [19] [20] [21]22]. Drug-coated stainless steel solid MN was able to deliver only 69 % of ...
http://drugdelivery.chbe.gatech.edu/Papers/2007/Jiang%20IOVS%202007.pdf
Coated Microneedles for Drug Delivery to the Eye Jason Jiang,1,2 Harvinder S. Gill,3 Deepta Ghate,1 Bernard E. McCarey,1 Samir R. Patel,2 Henry F. Edelhauser,*,1 and Mark R. Prausnitz*,2,3 PURPOSE. To test the hypothesis that coated microneedles can deliver drugs into …
http://drugdelivery.chbe.gatech.edu/Papers/2009/Jiang%20Pharm%20Res%202009.pdf
Research Paper Intrascleral Drug Delivery to the Eye Using Hollow Microneedles Jason Jiang,1 Jason S. Moore,1 Henry F. Edelhauser,2 and Mark R. Prausnitz1,3 Received July 11, 2008; accepted October 10, 2008; published online November 1, 2008
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038673/
This work introduced a minimally invasive strategy for drug delivery to the back of the eye. It showed that a hollow microneedle can inject liquid solution and suspensions of particles into the suprachoroidal space of rabbit, pig, and human eyes ex vivo. Suprachoroidal delivery represents an improvement over current periocular and intravitreal ...Author: Samirkumar R. Patel, Angela S. P. Lin, Henry F. Edelhauser, Mark R. Prausnitz
https://link.springer.com/article/10.1007/s11095-008-9756-3
Nov 01, 2008 · Results. Individual hollow microneedles were able to insert into sclera. Fluid infusion was extremely slow after microneedle insertion into the sclera without retraction, but partial retraction of the microneedle over a distance of 200–300 μm enabled infusion of 10–35 μl of fluid into the tissue.Author: Jason Jiang, Jason S. Moore, Henry F. Edelhauser, Mark R. Prausnitz
https://drum.lib.umd.edu/bitstream/handle/1903/3609/umi-umd-3457.pdf;sequence=1
The main goal of ocular drug delivery is controlled release of therapeutic concentrations to specific tissues while avoiding systemic spread of the formulation. However, the eye presents several anatomic and physiologic barriers that pose a major challenge for targeted drug delivery, especially to …
https://www.sciencedirect.com/science/article/pii/B9780123705853500042
I. INTRODUCTION. Ophthalmic drug delivery systems are essential to improve duration, targeting and compliance. For chronic diseases such as glaucoma, macular degeneration and diabetic retinopathy, administration routes can include oral, parenteral, topical, subconjunctival, intracameral, intravitreal, sub-Tenon's, intrascleral, and subretinal.Author: Alan L. Weiner
https://www.ondrugdelivery.com/7049-2/
IONTOPHORESIS. Iontophoresis, application of a low-intensity electrical current, enhances drug delivery across biological membranes by causing electrorepulsion and electro-osmosis of the drug molecule. 2,3 Electrorepulsion primarily applies to the movement of ionic drugs, 4 while electro-osmosis can enhance the transport of both neutral and charged molecules by convective solvent flow. 5 The ...
https://www.sciencedirect.com/science/article/pii/S0169409X01001934
Oct 31, 2001 · The utilization of some type of sustained-release delivery system would thus appear to be necessary for the successful utilization of transscleral drug delivery. An ideal sustained-release transscleral delivery system would provide controlled, long-term drug release, specific scleral site delivery, and prolong drug–sclera contact time.Author: Dayle H Geroski, Henry F Edelhauser
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