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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242656/
Moreover, pre-existing nephropathy, neuropathy, and retinopathy have been surprisingly stable. With an aggressive policy of catheter change or laparoscopic clearance of catheter blockage, long-term intraperitoneal insulin delivery is now a safe and effective treatment for type I diabetics.Author: Henry A. Pitt, Christopher D. Saudek, Howard A. Zacur
https://www.ncbi.nlm.nih.gov/pubmed/28474383
May 05, 2017 · Intraperitoneal Insulin Delivery Provides Superior Glycemic Regulation to Subcutaneous Insulin Delivery in Model Predictive Control-based Fully-automated Artificial Pancreas in Patients with Type 1 Diabetes: A Pilot Study.Author: Eyal Dassau, Eyal Dassau, Eric Renard, Eric Renard, Jérôme Place, Anne Farret, Anne Farret, Marie‐Jo...
https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.12999
Intraperitoneal insulin delivery provides superior glycaemic regulation to subcutaneous insulin delivery in model predictive control‐based fully‐automated artificial pancreas in patients with type 1 diabetes: a pilot study. Eyal Dassau PhD.Author: Eyal Dassau, Eyal Dassau, Eric Renard, Eric Renard, Jérôme Place, Anne Farret, Anne Farret, Marie‐Jo...
http://theiipump.com/index.php/comparing-normal-intraperitoneal-and-subcutaneous-insulin-delivery/
Intraperitoneal (IP) insulin delivery supports the maintenance of this Positive Portal-Peripheral Insulin Gradient while Subcutaneous (SubQ) insulin delivery does just the opposite and creates an abnormal Negative Portal-Peripheral Insulin Gradient where the insulin concentration reaching the liver is lower than the concentration of insulin in the rest of the body. This contributes to the difficulty of maintaining …
https://care.diabetesjournals.org/content/33/1/121
Jan 01, 2010 · The closed-loop system is made up of three components: a subcutaneous glucose sensor, the insulin delivery algorithm (running on a laptop computer), and the intraperitoneal insulin infusion pump. The computer receives sensor data using a radiofrequency protocol and sends commands to the pump using the Bluetooth protocol.Author: Eric Renard, Jerome Place, Martin Cantwell, Hugues Chevassus, Cesar C. Palerm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Clinical trials have shown safety and efficacy of intraperitoneal insulin delivery.[96,97] The limitations of this route of insulin administration include it is invasive, may be associated with subcutaneous infections, cannula blockage, higher cost, portal-vein thrombosis and peritoneal infection.
https://diabetes.diabetesjournals.org/content/28/12/1069
Dec 01, 1979 · Successful implantation of an artificial pancreas requires the infusion of insulin into an appropriate anatomic site. Three sites being actively investigated include (1) intravenous (i.V.), (2) intraperitoneal (i.p.), and (3) subcutaneous (s.c). This study compared the rate, magnitude, and duration of insulin absorption from these three absorption sites as assessed by the appearance of “free ...Author: Schade Ds, Eaton Rp, Friedman N, Spencer W
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769765/
Intraperitoneal Insulin Delivery: A Physiological Model. From initial experiments performed in animals in the 1970s, a clearly predominant absorption of IP-infused insulin via the portal venous system has been demonstrated.Author: Eric Renard
https://www.advancesinpd.com/adv94/26versus94.html
For the diabetic patient on peritoneal dialysis, the intraperitoneal administration of insulin can lead to improvement in glycemic control while eliminating uncomfortable subcutaneous injections. Furthermore, the relatively higher portal vein concentrations of insulin compared to peripheral levels is reminiscent of the physiologic state in which the portal vein carries the insulin secreted by the pancreas.
https://professional.diabetes.org/abstract/intraperitoneal-ip-insulin-infusion-versus-subcutaneous-sc-insulin-administration-type-1
Intraperitoneal (IP) Insulin Infusion versus Subcutaneous (SC) Insulin Administration in Type 1 Diabetes (T1DM): Preliminary Results of a Prospective Randomized Cross-over Trial As part of an ongoing cross-ov As part of an ongoing cross-over trial to compare the effects of IP insulin to SC insulin in poorly controlled T1DM (HbA 1c [gt]7.5% and/or [ge]5 hypoglycemic events/wk), preliminary data ...
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