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https://www.ncbi.nlm.nih.gov/pubmed/22465159
Intranasal administration is a non-invasive route for drug delivery, which is widely used for the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the systemic circulation through the nasal mucosa, this route may also be used in a range of acute or chronic conditions requiring considerable systemic exposure.Author: Stanislas Grassin-Delyle, Amparo Buenestado, Emmanuel Naline, Christophe Faisy, Sabine Blouquit-Laye...
http://intranasal.net/Overview/default.htm
Drug volume discussion. The volume of drug administered is a poorly studied but important clinical concept for those who are interested in a deeper understanding of intranasal medication delivery and the pharmaceutical/FDA approach to dosing and concentration versus the approach of clinicians who just want to help their patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
https://www.celerion.com/wp-content/uploads/2015/05/Celerion_050515_TIDES_Intranasal-Drug-Delivery.pdf
(2012) Drug development of intranasally delivered peptides. Therapeutic Delivery 3(4), 557-568 Dhuria SV, Hanson LR, Frey WH, 2nd (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99(4), 1654-1673 Merkus FW, Van Den Berg MP (2007) Can nasal drug deliveryFile Size: 1MB
https://med.umkc.edu/docs/em/Intranasal_drug_delivery.pdf
Intranasal drug delivery - General principles The nasal cavity's easily accessible, rich vascular plexus permits topically administered drugs to rapidly achieve effective blood levels while avoiding intravenous catheters. This is most effectively accomplished by distributing drug solutions as a mist rather than as larger droplets which may
http://intranasal.net/Peer%20Reviewed%20literature/Pires,%20Intranasal%20drug%20delivery%20-%20How%20why%20%20what%20for%20-extensive%20review,%20J%20Pharm%20Pharmaceut%20Sci%202009.pdf
J Pharm Pharmaceut Sci (www.cspsCanada.org) 12(3) 288 - 311, 2009 288 Intranasal Drug Delivery: How, Why and What for? Anaísa Pires 1,2, Ana Fortuna , Gilberto Alves2,3 and Amílcar Falcão1,2 1 Pharmacology Department, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.2 Centre for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
https://www.intechopen.com/books/drug-discovery-and-development-from-molecules-to-medicine/intranasal-drug-administration-an-attractive-delivery-route-for-some-drugs
One of the first steps in approaching the development of an intranasal drug administration project is to select the appropriate system for delivering the drug formulation. The selection of the delivery system is strongly governed by the type of formulation envisaged for delivery.Author: Degenhard Marx, Gerallt Williams, Matthias Birkhoff
https://www.sciencedirect.com/science/article/pii/S0169409X97000604
An attempt to quantitatively determine the significance of this pathway to the delivery of drugs to the brain tissue, the CSF as well as the olfactory bulbs, l-dopa levels were determined after intranasal and intravenous administration of a water soluble prodrug of l-dopa, the butyl ester of l-dopa.Author: Anwar A Hussain
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