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https://www.ncbi.nlm.nih.gov/pubmed/2862235
Intranasal drug delivery by spray and drops. Hardy JG, Lee SW, Wilson CG. A solution of 99mTc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in …Author: J. G. Hardy, S. W. Lee, C. G. Wilson
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1985.tb05069.x
A solution of 99m Tc‐labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in normal subjects were ...Author: J. G. Hardy, S. W. Lee, C. G. Wilson
http://intranasal.net/Overview/default.htm
Multiple studies show that the atomized pump is the best nasal delivery system because it gives a constant dose and a very good mucosal distribution.[2, 3] In addition, research has demonstrated that clearance of spray is much slower than clearance of drops[4] since much of the spray deposits on nonciliated areas, whereas nose drop solutions are primarily distributed on ciliated surfaces.
http://intranasal.net/DeliveryTechniques/deliverytechniqueabstracts.htm
"Intranasal drug delivery by spray and drops." J Pharm Pharmacol 37(5): 294-7. A solution of 99mTc-labelled human serum albumin was administered into the nose as a spray and as one or three drops.
https://www.deepdyve.com/lp/wiley/intranasal-drug-delivery-by-spray-and-drops-wMxUsIOODp
Intranasal drug delivery by spray and drops The patterns of deposition and the rates of clearance in normal subjects were monitored by gamma scintigraphy. The spray was deposited mainly in the atrium, and cleared slowly into the pharynx.
https://www.contractpharma.com/issues/2019-01-01/view_features/nasal-drug-delivery
Drug delivery to the nasal cavity: In vitro and in vivo assessment. Crit Rev Ther Drug Carrier Syst 2004; 21: 21-66 FDA Guidance for Industry: Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products – Chemistry, Manufacturing, and Controls Documentation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Metered-dose spray pumps. Metered spray pumps have, since they were introduced some four decades ago, dominated the nasal drug delivery market (Table 1). The pumps typically deliver 100 μl (25–200 μl) per spray, and they offer high reproducibility of the emitted dose and plume geometry in in vitro tests.Author: Per Gisle Djupesland
https://www.slideshare.net/naveen_kasagana/nasal-drug-delivery
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