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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Intranasal delivery to the CNS is an especially useful technique because not only is it rapid, but it targets the CNS reducing systemic exposure. For example, intranasal administration of deferoxamine to rats resulted in 3-19 times higher concentrations in brain regions with 28 times lower concentrations in the blood 11 .Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.sciencedirect.com/science/article/pii/S0022354916304841
The intranasal route of administration is not a novel approach for drug delivery to the systemic circulation. The novelty lies in using this noninvasive method to rapidly deliver drugs directly from the nasal mucosa to the brain and spinal cord with the aim of treating CNS disorders while minimizing systemic exposure.Author: Shyeilla V. Dhuria, Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey, William H. Frey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761088/
Nov 08, 2012 · However, while intranasal delivery may, in general, produce a favorable side-effect profile as compared to other delivery routes, each drug must be examined for its particular effects on the nasal mucosa, the sense of smell and the immune system as the drug will likely enter not only the CNS but also the nasal associated lymphatics and deep cervical lymph nodes.Author: Colin D. Chapman, William H. Frey, Suzanne Craft, Lusine Danielyan, Manfred Hallschmid, Helgi B. Sch...
https://drug-dev.com/cns-delivery-bypassing-the-bbb-drug-delivery-from-the-olfactory-mucosa-to-the-cns/
Intranasal olfactory mucosal administration of therapeutic agents for the treatment of neurodegenerative and many CNS diseases overcomes the limitations due to the BBB, and provides an effective direct delivery method for a selective group of therapeutic agents to treat the brain regions that are pathologically affected with Alzheimer’s and Parkinson’s disease as well as other CNS diseases.
https://www.thepharmaeducation.com/2020/04/Nasal-Drug-Delivery-System.html
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https://www.sciencedirect.com/science/article/pii/S0361923018303678
Intranasal drug transport through the olfactory route to the CNS by intracellular and extracellular pathways. Drug is taken up by OSNs which project to the olfactory bulb.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
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