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https://www.sciencedirect.com/science/article/pii/S0022354916304841
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations. ... Pathways of drug distribution in the nasal cavity and central nervous system. Following intranasal administration, drugs (blue circles) come into contact with the nasal mucosa, which is innervated by olfactory and trigeminal nerves. ...Author: Shyeilla V. Dhuria, Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey, William H. Frey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
https://www.ncbi.nlm.nih.gov/pubmed/22119441
May 15, 2012 · Intranasal delivery of biologics to the central nervous system. Lochhead JJ(1), Thorne RG. Author information: (1)Pharmaceutical Sciences Division, University of Wisconsin-Madison School of Pharmacy, Madison, WI 53705, USA.Author: Jeffrey J. Lochhead, Robert G. Thorne
https://quizlet.com/395407645/central-nervous-system-delivery-of-drugs-intranasal-delivery-and-gene-therapy-flash-cards/
In recent years it has been appreciated that the intranasal route of delivery may have a unique direct pathway to the CNS as well. A significant line of investigation in this area is the potential for development of non-invasive delivery methods for large macromolecular protein and peptide biological therapeutics to the central nervous system.
https://www.sciencedirect.com/science/article/pii/S0169409X11002791
Treatment of central nervous system (CNS) diseases is very difficult due to the blood–brain barrier's (BBB) ability to severely restrict entry of all but small, non-polar compounds. Intranasal administration is a non-invasive method of drug delivery which may bypass the BBB to allow therapeutic substances direct access to the CNS.Author: Jeffrey J. Lochhead, Robert G. Thorne
https://www.researchgate.net/publication/51836420_Intranasal_Delivery_of_Biologics_to_the_Central_Nervous_System
Intranasal Delivery of Biologics to the Central Nervous System Article · Literature Review (PDF Available) in Advanced drug delivery reviews 64(7):614-28 · November 2011 with 1,730 Reads
https://link.springer.com/article/10.1007/s11095-012-0915-1
Nov 08, 2012 · One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For example, a variety of compounds have beneficial effects within the central nervous system (CNS), but unwanted side effects in the periphery. For such compounds, traditional oral or intravenous drug delivery fails to provide benefit without cost ...Author: Colin D. Chapman, William H. Frey, Suzanne Craft, Lusine Danielyan, Manfred Hallschmid, Helgi B. Sch...
https://onlinelibrary.wiley.com/doi/full/10.1002/jps.21924
Oct 28, 2009 · This review focuses on the current understanding of the mechanisms underlying intranasal delivery to the CNS, with a discussion of pathways from the nasal cavity to the CNS involving the olfactory and trigeminal nerves, the vasculature, the cerebrospinal fluid, and the lymphatic system.Author: Shyeilla V. Dhuria, Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey, William H. Frey
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118788523.ch25
Summary This chapter discusses the scientific developments of nose‐to‐brain delivery of drugs in the past 10 years and the use of ... Intranasal Delivery to the Central Nervous System. Lisbeth Illum. ... and the factors affecting nose‐to‐brain delivery from the olfactory nerve region and through the trigeminal nerve system are described ...Author: Lisbeth Illum
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