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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · Nose-to-brain (N2B) delivery allows application of drugs at the roof of the nasal cavity, which are transported to the central nervous system (CNS) of humans (A) and rodents (B).N2B transport can either be mediated via the olfactory or the trigeminal pathway.Author: Stella Gänger, Katharina Schindowski
https://www.sciencedirect.com/science/article/pii/S0361923018303678
Some studies focused on nose to brain delivery in humans utilized the Vianase™ a delivery system designed e.g. to delivery insulin intranasally (Craft et al., 2012). Vianase™ is an electronic atomizer device developed by Kurve Technology ® which consists of a nebulizer attached to a vortex chamber.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.nature.com/articles/nb.1866
Jun 07, 2011 · Intranasal delivery to the brain. To date, the majority of studies investigating this delivery mechanism have looked only at animal models 11, but both short- …Author: Robert I Henkin
https://www.sciencedirect.com/science/article/pii/S0378517319304090
The PLGA NPs conjugated to N-trimethylated chitosan have been prepared for efficient intranasal delivery of huperzine A to the brain for AD treatment, and the ephrin type-A receptor 3 tyrosine kinase antibody has also been used to modify the surface of the PLGA NPs to target glioblastoma via nose to brain delivery (Chu et al., 2018, Meng et al ...Author: Tingwang Guo, Tingwang Guo, Yuanyuan Guo, Yuhua Gong, Jingou Ji, Shilei Hao, Jia Deng, Jia Deng, Boc...
http://intranasal.net/Overview/default.htm
Intranasal medication delivery - brief overview of the concept. Disclaimer: The information on this web site is for educational and informational purposes only. It is not professional medical advice nor is it intended to substitute for such.
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · One of the first reports on the delivery of peptides to the brain involved the intranasal delivery of insulin to the brain in an insulin solution (Sigurdsson et al., 1997). Pharmacological activity has been observed in clinical studies, yet preclinical studies reveal just how little of the applied dose is actually delivered to the brain.Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
Intranasal delivery of biologics to the central nervous system. Adv Drug Del Rev. 2012;64:614-628. 13. Gizurarson S. Anatomical and histological factors affecting intranasal drug and vaccine delivery. Curr Drug Deliv. 2012;9:566-582. 14. Dalpiaz A, et al. Brain uptake of a Zidovudine prodrug after nasal administration of solid lipid microparticles.
http://intranasal.net/Peer%20Reviewed%20literature/Talegaonkar,%20Intranasal%20delivery%20-%20An%20approach%20to%20bypass%20the%20blood%20brain%20barrier,%20I%20J%20Pharm%202004.pdf
Intranasal delivery: An approach to bypass the blood brain barrier S. Talegaonkar, P. R. Mishra ABSTRACT The blood brain barrier (BBB) represents one of the strictest barriers of in vivo therapeutic drug delivery. The barrier is defined by restricted exchange of hydrophilic compounds, small proteins
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