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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired.Author: Per Gisle Djupesland
http://med.umkc.edu/docs/em/IN_Med_dosing_chart.pdf
Intranasal medications and doses based on published literature Clinical Scenario Intranasal Medication and dose Important reminders Pain control Fentanyl 2.0 ug/kg Ketamine 0.5 to 1 mg/kg •Always monitor for respiratory depression • Only use a device that can …File Size: 87KB
http://www.intranasal.net/PainControl/Pain_Control_overview.htm
Intranasal Pain Medications Overview Topic summary: Nasal delivery of pain medication is an attractive form of pain control in settings where patients are suffering severe pain, yet do not have any IV access.
https://www.sciencedirect.com/science/article/pii/S0939641114000812
In addition, the current recognition that the high permeability and vascularization of nasal mucosa coupled to the avoidance of the first-pass elimination and/or gastrointestinal decomposition ensure higher systemic drug absorption than oral route has contributed to the growing interest for intranasal delivery of drugs that require considerable ...Author: Ana Fortuna, Gilberto Alves, Gilberto Alves, Ana Serralheiro, Joana Sousa, Amílcar Falcão
http://intranasal.net/Overview/default.htm
Drug volume discussion. The volume of drug administered is a poorly studied but important clinical concept for those who are interested in a deeper understanding of intranasal medication delivery and the pharmaceutical/FDA approach to dosing and concentration versus the approach of clinicians who just want to help their patients.
https://www.intechopen.com/books/drug-discovery-and-development-from-molecules-to-medicine/intranasal-drug-administration-an-attractive-delivery-route-for-some-drugs
One of the first steps in approaching the development of an intranasal drug administration project is to select the appropriate system for delivering the drug formulation. The selection of the delivery system is strongly governed by the type of formulation envisaged for delivery.Author: Degenhard Marx, Gerallt Williams, Matthias Birkhoff
https://www.ncbi.nlm.nih.gov/pubmed/20067706
Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased.Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action.Author: Anaísa Pires, Ana Fortuna, Gilberto Alves, Amílcar Falcão
https://www.woodlandhillspharmacy.com/nasal-drug-delivery/
Nov 05, 2018 · It is only recently that the nasal delivery method has become more popular. Research into nasal drug delivery is increasing as new intranasal drugs are brought to market. In the meantime, compounding pharmacies are helping patients get the nasal medications they need that are not yet commercially available. Systemic vs. Local Effects
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