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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015522/
Intra-articular (IA) drug delivery presents many advantages as it offers direct access to the joint space, thus increasing the bioavailability of therapeutic agents at the affected site while reducing systemic exposure, potential side effects and overall cost.Author: Muhammad Farooq Rai, Christine T.N. Pham
https://www.ncbi.nlm.nih.gov/pubmed/29792929
To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.sciencedirect.com/science/article/pii/S1359644618300461
Recent advances in intra-articular drug delivery systems for osteoarthritis therapy. Author links open overlay panel Pierre Maudens Olivier Jordan Eric Allémann. Show more. ... He owns nine patents, two of which are in the field of gel technology and have led to clinical applications. He has authored 65 peer-reviewed publications.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
http://www.eurekaselect.com/92876/article
The utilization of the intra-articular route for the delivery of drugs and other macromolecules has recently evolved making use of the avascularity of the cartilage tissue to allow regional administration of the drug within the joint space rather than the systemic circulation.Author: Maha Nasr Sayed Aly
https://www.sciencedirect.com/science/article/pii/S1471489217301431
Introduction Intra-articular (IA) drug delivery presents many advantages as it offers direct access to the joint space, thus increasing the bioavailability of therapeutic agents at the affected site while reducing systemic exposure, potential side effects and overall cost.Author: Muhammad Farooq Rai, Christine T.N. Pham
http://medicalmilestone.com/
Milestone Medical, Inc. has developed epidural and intra-articular drug delivery systems based on a patented, painless, computer-controlled injection and drug delivery technology originally developed by Milestone Scientific, Inc.
https://www.aiche.org/resources/publications/cep/2018/may/designing-drug-delivery-systems-articular-joints
Intra-articular injection is commonly used for local drug delivery into knee joints. However, upon injection into the fluid-filled joint capsule encased in the synovial membrane (or synovium), the drug is typically lost to systemic circulation within a matter of hours to days.
https://www.nature.com/articles/s41584-018-0123-4
Nov 29, 2018 · Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for …Author: Ian A. Jones, Ryan Togashi, Melissa L. Wilson, Nathanael Heckmann, C. Thomas Vangsness
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