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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702533/
Localized drug delivery via intra-articular injections minimizes ectopic effects while alleviating joint pain and other symptoms. Although the Food and Drug Administration (FDA) has only approved intra-articular hyaluronic acid formulations for osteoarthritis of the knee, these formulations are still used to treat pain in a number of other joints, including the TMJ [ 5 , 9 ].Author: Paschalia M. Mountziaris, Phillip R. Kramer, Antonios G. Mikos
https://clinicalgate.com/parenteral-drug-delivery/
Intra-arterial and intracardiac injections The large majority of drugs that are administered parenterally are given intravenously. As noted above, this delivers the drug directly into the blood stream to provide a rapid and predictable clinical effect. However, it is not the only way that medicines can be administered into the vascular system.
https://www.ncbi.nlm.nih.gov/pubmed/29792929
To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.sciencedirect.com/science/article/pii/S0939641109001945
Treatment of irreversible joint damage is achieved through oral, parenteral or intra-articular drugs. Despite some practical drawbacks, the direct delivery of a drug to an affected joint offers the possibility of reaching high drug concentrations at the site of action with limited systemic toxicity. The i-a.Author: Nicoleta Paula Butoescu, Olivier Jordan, Eric Doelker
https://www.tandfonline.com/doi/abs/10.1517/17425240802647259
Jan 11, 2016 · Abstract Background : Intra-articular drug delivery is very useful for treating local disease flare-ups, synovitis and pain in joints. However, the effectiveness of drugs following intra-articular administration is limited by drug delivery issues.Author: Helen M Burt, Antonia Tsallas, Samuel Gilchrist, Linda S Liang
https://www.nature.com/articles/s41584-018-0123-4
Nov 29, 2018 · Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for the management of knee osteoarthritis (OA) have been limited to analgesics, glucocorticoids, hyaluronic acid (HA) and a small number of unproven alternative therapies.Author: Ian A. Jones, Ryan Togashi, Melissa L. Wilson, Nathanael Heckmann, C. Thomas Vangsness
https://www.hindawi.com/journals/jnt/2012/748909/
Intra-articular drug delivery can be a good means of targeting drug to the large joints (knees and hips) and has been expected to gain prominence for several reasons, such as only a minimum amount of drug is required to exert the desired pharmacological activity.Author: Zhiyue Zhang, Guihua Huang
https://quizlet.com/204165898/parenteral-drug-delivery-flash-cards/
Emboli, phlebitis, clear and particulate free = <50 particles of 10mcm or larger per mL for LVP's. Back up: In-line filters can be helpful to reduce the number of particles in solution of parenteral. Explain why a parentaral solution should be isotonic but why this is not always possible.
https://pdfs.semanticscholar.org/d388/a5f129118f5de57f62a37c4b52dd70d27b02.pdf
Intra-articular drug delivery system is used for the treatment of arthritis as it is given directly into the bone joints. It avoids the side effects caused by other routes like oral, parenteral, topical etc. [1-3].
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