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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014105/
To our knowledge, this is the first intra-articular microparticle-based drug delivery system for the TMJ. The impact of PLGA MP concentration on rat TMJ function was quantified via computerized meal pattern analysis; in this non-invasive technique, previously validated markers of TMJ pain or nociception (specifically, meal duration and food intake) were recorded by computer-monitored pellet feeders.Author: P.M. Mountziaris, D.C. Sing, A.G. Mikos, P.R. Kramer
https://www.ncbi.nlm.nih.gov/pubmed/20660799
To our knowledge, this is the first intra-articular microparticle-based drug delivery system for the TMJ. The impact of PLGA MP concentration on rat TMJ function was quantified via computerized meal pattern analysis; in this non-invasive technique, previously validated markers of TMJ pain or nociception (specifically, meal duration and food intake) were recorded by computer-monitored pellet feeders.Author: P.M. Mountziaris, D.C. Sing, A.G. Mikos, P.R. Kramer
http://europepmc.org/articles/PMC3014105
Oct 01, 2010 · Intra-articular microparticles did not induce TMJ pain or nociception, based on (a) meal duration and (b) food intake measurements for 2 days prior to and 6 days following intra-articular injection of 15, 30, or 50 mg/mL PLGA microparticle formulations (abbreviated “PLGA”). A dashed line indicates the time of injection.
https://www.researchgate.net/publication/45366404_Intra-articular_Microparticles_for_Drug_Delivery_to_the_TMJ
Microparticles of PLGA have been revealed to be biocompatible and suitable for intra-articular delivery to TMJ in rat and therefore can support regenerative strategies [154]. Controlled release of anti-inflammatory siRNA from biodegradable microparticles of PLGA have been proposed for intra-articular delivery to TMJ [155]. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702533/
This section discusses microparticles, liposomes, and other emerging drug delivery systems that promise to greatly improve intra-articular drug delivery to the TMJ. Intra-articular hyaluronic acid formulations consist of colloidal dispersions of HA in aqueous solution, which form hydrogel structures . In the United States, these agents are the only microcarrier-based intra-articular formulations …Author: Paschalia M. Mountziaris, Phillip R. Kramer, Antonios G. Mikos
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954570/
Keywords: Temporomandibular joint, therapeutics delivery, nano/microparticles, intra-articular injection, temporomandibular joint disorder, myofascial pain syndrome Introduction The temporomandibular joint (TMJ) is a bilateral joint (synovial articulation) between the condyle (head of mandible) and part of skull (upper temporal bone).
https://journals.sagepub.com/doi/10.1177/2041731418776514
May 13, 2018 · Intra-articular stem cell delivery with nano/microparticles for accelerating the regeneration of damaged TMJ. For intra-articular delivery of stem cells, typical hydrogel-based microparticles were initially utilized, which allow injection after gelation.Author: Khandmaa Dashnyam, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Hae-Hyoung Lee, Hae-Won Kim
https://www.sciencedirect.com/science/article/pii/S1046202308001497
The emerging intra-articular drug delivery systems described in this paper have the potential to both treat pain associated with TMJ disorders and deliver growth factors and other signals to control the underlying joint degeneration.Author: Paschalia M. Mountziaris, Phillip R. Kramer, Antonios G. Mikos
https://www.researchgate.net/publication/325124722_Intra-articular_biomaterials-assisted_delivery_to_treat_temporomandibular_joint_disorders/fulltext/5af99f560f7e9b026bf7484f/325124722_Intra-articular_biomaterials-assisted_delivery_to_treat_temporomandibular_joint_disorders.pdf
for effective intra-articular therapeutics delivery to prevent cartilage degradation and protect subchondral bone in a temporomandibular joint. Keywords
https://www.researchgate.net/publication/325124722_Intra-articular_biomaterials-assisted_delivery_to_treat_temporomandibular_joint_disorders
Intra-articular injection: injection with syringe and needle can deliver proper biomolecules into TMJ capsule for treating TMD. Nano and microparticles have the potential to deliver various...
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