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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Continuous subcutaneous insulin infusion. More physiologic delivery of insulin has been a long-standing goal. In normal physiology, a continuous small amount of insulin secretion from the beta cells of the pancreas reduces hepatic glucose output, and a larger amount of insulin is secreted when food is ingested to maintain euglycemia.[] Although multiple daily injections (MDI) therapy can ...
https://www.webmd.com/diabetes/inhaled-insulin
Inhaled insulin is another option for people with diabetes to control their blood sugar. It works for both type 1 and type 2 diabetes, but you shouldn't use it if you smoke or have asthma or COPD.
https://www.diabetes.co.uk/insulin/Diabetes-and-insulin-delivery-devices.html
There are many different types of insulin delivery devices available including syringes, pens, jet injectors, oral insulin and pumps which are detailed below. Furthermore, insulin that can be inhaled and other new approached to insulin treatment are at different stages of availability and …
https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/ways-deliver-insulin-inhalers-insulin-pumps/
Sep 18, 2019 · We recently looked at two ways to deliver (in this case, inject) insulin: insulin syringes and insulin pens.While most people with type 1 diabetes are familiar with at least one of these methods, it’s natural to be curious about other options, especially if it means giving yourself fewer injections. Here’s where inhaled insulin and insulin pumps come in.Author: Amy Campbell, MS, RD, LDN, CDE
Afrezza is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus. Afrezza is not for use in place of long-acting insulin. Afrezza must be used with long-acting insulin in people who have type 1 diabetes mellitus.
https://www.ondrugdelivery.com/overview-dry-powder-inhalation-systemic-drug-delivery/
An extensive review in 2005 highlighted the advantages of using a carrier based system for delivery: APIs do not innately have the necessary properties and therefore formulations with inert carriers are required for deep lung penetration. 3 Carriers have many advantages, enabling more API powder to reach the site of absorption, improving the in vivo API stability and improving product taste.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835554/
Mar 03, 2010 · Delivery of insulin via inhalation is a potential alternative to subcutaneous insulin in the management of diabetes. This review will discuss the rationale for development of pulmonary delivered versions of insulin as well as discuss the role that inhaled insulin may play in …Author: Lucy D Mastrandrea
https://www.pnas.org/content/98/20/11103
Sep 25, 2001 · In rats, the bioavailability of insulin delivered via this approach was comparable to those observed in the inhalation delivery of insulin aqueous solutions or conventional dry powders. Inhalation delivery of proteins from ethanol suspensions is free of many inherent drawbacks of the aqueous and dry powder approaches.Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.mannkindcorp.com/Collateral/Documents/English-US/Innovation%20In%20Drug%20Delivery%20by%20Inhalation.pdf
fomulation technologies and delivery devices the company is developing for drug, including insulin, delivery to the systemic circulation via the lungs. INNOVATION IN DRUG DELIVERY BY INHALATION Andrea Leone-Bay Vice-President, Pharmaceutical Development T: +1 203 796 3421 F: +1 203 798 7740 E: [email protected] Dr Robert Baughman
https://www.lifeextension.com/Magazine/2015/2/Health-Risks-Of-Inhalation-Insulin-For-Diabetics/
Some of the areas of investigation include aerosolized insulin for inhalation, oral insulin, insulin-producing stem cell implantation, insulin delivery pumps, and more. 25 There is even possible development of microneedles to deliver insulin subcutaneously, along with various transdermal and transmucosal delivery of insulin without needles.
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