We have collected information about Interstitial Drug Delivery for you. Follow the links to find out details on Interstitial Drug Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734291/
Interstitial fluid is a solution that bathes and surrounds the human cells and provides them with nutrients and a way of waste removal. It is generally believed that elevated tumor interstitial fluid pressure (IFP) is partly responsible for the poor penetration and distribution of therapeutic agents in solid tumors, but the complex interplay of extravasation, permeabilities, vascular ...Author: Michael Welter, Heiko Rieger
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664547/
Nov 23, 2015 · Drug-delivery systems (DDSs) have been introduced to control rate, time, and place of release. Drugs can easily reach the bladder through a catheter, while systemically administered agents may undergo extensive metabolism. Continuous urine filling and subsequent washout hinder intravesical drug delivery (IDD).Author: Martino Maria Zacchè, Sushma Srikrishna, Linda Cardozo
https://www.sciencedirect.com/science/article/pii/S0142961214010485
Bi 2 S 3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization. ... thus leading to various advantages in drug delivery such as high drug loading capacity and controlled drug release property , . As we expected, BMSNs exhibit high drug loading efficacy of 45 wt% for DOX drug.Author: Ming Ma, Yan Huang, Hangrong Chen, Xiaoqing Jia, Shige Wang, Zizheng Wang, Jianlin Shi
https://www.sciencedirect.com/science/article/pii/S2211339814000896
Drug delivery approaches and design for interstitial-, lymphatic-, and lymph node-targeting. We now consider the material design to achieve targeting of the tissues described above, focusing on the relevant tissue physiology as a guide for the engineering of the therapeutic or imaging agent formulation.Author: Susan N Thomas, Alex Schudel
https://www.youtube.com/watch?v=JHk84vRjQzk
Feb 11, 2016 · Dr Brem talks to ecancertv at Children with Cancer UK’s workshop on Drug Delivery in Paediatric Brain Tumours in London, UK. He discusses the use of …
https://link.springer.com/chapter/10.1007/978-3-540-92841-6_561
Recent anticancer drugs are made to be larger to selectively pass the tumor vessel and to stay in the interstitium. Understanding of the drug movement in a single molecule is indispensable to optimize drug delivery. Here we report the tracking of single nano-particles with different sizes in tumor xenografts in vivo. The motions of the nano ...Author: M. Kawai, M. Takeda, N. Ohuchi
https://www.slideshare.net/sayedasalma/brain-specific-delivery
Jul 24, 2018 · INTERSTITIAL DELIVERY • Interstitial drug delivery can theoretically yield high CNS drug concentrations with minimal systemic exposure and toxicity. • Intracranial drug concentrations can be sustained, which is crucial in treatment with many chemotherapeutic agents. 57 58.
https://clincancerres.aacrjournals.org/content/11/2/826
Jan 15, 2005 · Abstract. Purpose: Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel to the whole tumor at different loads and rates has already been achieved, determining an optimal release mode of paclitaxel for tumor eradication remains difficult.Author: Abraham Rami Tzafriri, Elyakum Itzhak Lerner, Moshe Flashner-Barak, Michael Hinchcliffe, Eli Ratner,...
https://www.nature.com/articles/nrc1456
Oct 01, 2004 · High interstitial fluid pressure — an obstacle in cancer therapy. ... Bacterial proteolytic activity improves drug delivery in tumors in a size, pharmacokinetic, and binding affinity dependent ...Author: Carl-Henrik Heldin, Kristofer Rubin, Kristian Pietras, Arne Östman
https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.20182
The feasibility of such quantifications warrants future studies to investigate drug delivery efficiency using different types of contrast agents. This study suggests that multiple‐agent delivery to the interstitial space can be efficiently assessed in vivo with both spatial and temporal analyses using the presented method.Author: Y.R. Kim, Savellano, D.H. Savellano, R. Weissleder, A. Bogdanov
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