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http://www.authorstream.com/Presentation/sagarpharmavision-1202382-importance-of-partition-coefficient-in-formulation-development/
Sep 25, 2011 · Importance of Partition Coefficient in Formulation Development - authorSTREAM Presentation. Slide 2: The partition coefficient The lipophilicity of an organic compound is usually described in terms of a partition coefficient, log p, which can be defined as the ratio of the concentration of the unionized compound, at equilibrium, between organic and aqueous phases: Log P values have …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399483/
Jul 05, 2012 · 2. Importance of Solubility. Oral ingestion is the most convenient and commonly employed route of drug delivery due to its ease of administration, high patient compliance, costeffectiveness, least sterility constraints, and flexibility in the design of dosage form.Author: Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani
https://www.hindawi.com/journals/isrn/2012/195727/
2. Importance of Solubility. Oral ingestion is the most convenient and commonly employed route of drug delivery due to its ease of administration, high patient compliance, costeffectiveness, least sterility constraints, and flexibility in the design of dosage form.Author: Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani
https://www.dovepress.com/importance-of-the-formulation-in-the-skin-delivery-of-topical-diclofen-peer-reviewed-fulltext-article-JPR
Apr 12, 2019 · The pharmaceutical dosage form may also influence the drug delivery and kinetics. 29,36,37 Usually, drug formulated in biphasic formulation (emulsion, cream, and ointment) needs to partition out of the internal phase through the external phase before reaching the skin surface. This observation has been confirmed by Stahl et al who noticed a ...Author: Julie Pradal, Coralie M Vallet, Guillaume Frappin, Frédérique Bariguian, Maria Stella Lombardi
https://www.ondrugdelivery.com/function-based-primary-packaging-design-for-injecting-viscous-non-newtonian-formulations/
UNDERSTANDING FORMULATION DELIVERY. Understanding the physical characteristics of a drug formulation early in the product development process is of the utmost importance. It increases the likelihood of achieving the required specification and reduces the risk of unforeseen technical challenges later in development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489664/
Apr 12, 2019 · The pharmaceutical dosage form may also influence the drug delivery and kinetics.29,36,37 Usually, drug formulated in biphasic formulation (emulsion, cream, and ointment) needs to partition out of the internal phase through the external phase before reaching the skin surface. This observation has been confirmed by Stahl et al who noticed a ...Author: Julie Pradal, Coralie M Vallet, Guillaume Frappin, Frédérique Bariguian, Maria Stella Lombardi
https://www.sciencedirect.com/science/article/pii/S1740674912000145
In the last decade there has been a growing interest in lipid-based formulations to deliver challenging compounds such as lipophilic drugs. Following a brief clarification of the nomenclature, this review stresses the different mechanisms of how lipid-based excipients and formulations interact with the absorption process.Author: Martin Kuentz
https://www.quora.com/How-important-is-LogP-in-drug-design
Mar 13, 2014 · Quite important, log P can affect bioavailability, where the drug ends up in the body in the highest concentration, and it's ability to cross the blood-brain barrier. As I'm sure you're aware, log P is a measure of how hydrophobic or hydrophilic...
https://www.slideshare.net/SHANE_LOBO145/importance-of-partition-coefficient-solubility-and-dissociation-on-preformulation-studies
Mar 06, 2017 · Importance of partition coefficient, solubility and dissociation on pre-formulation studies Importance of partition coefficient, solubility and dissociation on pre-formulation studies ... Partition coefficient Importance: For drug delivery, the lipophilic/hydrophilic balance has been shown to be a contributing factor for the rate and extent of ...
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