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https://www.nature.com/articles/nrc1456
Oct 01, 2004 · Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in ...Author: Carl-Henrik Heldin, Kristofer Rubin, Kristian Pietras, Arne Östman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254664/
Nov 06, 2018 · While several mechanisms contributing to cancer drug resistance have been described, the common key barrier among solid cancers is the unique tumor microenvironment that causes the high interstitial fluid pressure (IFP). We discussed the mechanism causing an elevated IFP and how it interferes with drug delivery.Author: Steven K. Libutti, Lawrence Tamarkin, Naris Nilubol
https://www.ncbi.nlm.nih.gov/pubmed/7585615
Nov 15, 1995 · Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery. Netti PA(1), Baxter LT, Boucher Y, Skalak R, Jain RK. Author information: (1)Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA.Author: Paolo A. Netti, Laurence T. Baxter, Yves Boucher, Richard Skalak, Rakesh K. Jain
https://www.dovepress.com/interstitial-fluid-flow-in-cancer-implications-for-disease-progression-peer-reviewed-fulltext-article-CMAR
Interstitial fluid flow in cancer: implications for disease progression and treatment Jennifer M Munson,1 Adrian C Shieh2 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 2School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA Abstract: As cancer progresses, a dynamic microenvironment develops that creates and ...
https://cancerres.aacrjournals.org/content/55/22/5451
Nov 15, 1995 · Elevated interstitial fluid pressure (IFP) may constitute a significant physiological barrier to drug delivery in solid tumors. Strategies for overcoming this barrier have not been developed to date. To identify and characterize various mechanisms regulating IFP and to develop strategies for overcoming the IFP barrier, we modeled the tumor as a poroelastic solid. We used this model to simulate ...Author: Paolo A. Netti, Laurence T. Baxter, Yves Boucher, Richard Skalak, Rakesh K. Jain
https://www.sciencedirect.com/topics/engineering/interstitial-pressure
Conversely, net interstitial pressure was found to be reduced by 24 hours of dehydration, 346,482 and before and after release of 24 hour unilateral ureteral occlusion. 350 TGF reactivity was increased in these experimental situations. Exactly how net interstitial pressure affects TGF reactivity is unclear.
https://www.sciencedirect.com/science/article/pii/S0009250905002873
Transient interstitial fluid flow in brain tumors: Effect on drug delivery ... the mean values of interstitial pressure, fluid velocity and BCNU concentration would be reviewed and compared with relevant dimensionless numbers. The resection cavity will be discussed first, followed by the remnant tumor tissues and then the surrounding normal ...Author: Chee Seng Teo, Wilson Hor Keong Tan, Timothy Lee, Chi-Hwa Wang
https://www.researchgate.net/profile/Carl-Henrik_Heldin/publication/8207388_Heldin_CH_Rubin_K_Pietras_K_Ostman_AHigh_interstitial_fluid_pressure_-_an_obstacle_in_cancer_therapy_Nat_Rev_Cancer_4_806-813/links/53ec97270cf24f241f159009/Heldin-CH-Rubin-K-Pietras-K-Ostman-AHigh-interstitial-fluid-pressure-an-obstacle-in-cancer-therapy-Nat-Rev-Cancer-4-806-813.pdf
stitial fluid pressure (IFP) is a barrier for efficient drug delivery 2,3 .It is now well established that the IFP of most solid tumours is increased.This has been shown
https://www.researchgate.net/profile/Paolo_Netti/publication/15612752_Netti_PA_Baxter_LT_Boucher_Y_Skalak_R_Jain_RKTime-dependent_behavior_of_interstitial_fluid_pressure_in_solid_tumors_implications_for_drug_delivery_Cancer_Res_55_5451-5458/links/0fcfd50c1e879a93ce000000/Netti-PA-Baxter-LT-Boucher-Y-Skalak-R-Jain-RKTime-dependent-behavior-of-interstitial-fluid-pressure-in-solid-tumors-implications-for-drug-delivery-Cancer-Res-55-5451-5458.pdf
CANCER RESEARCH 55. 5451-5458. November 15, 1995! ABSTRACT Elevated interstitial fluid pressure (IFP) may constitute a significant physiological barrier to drug delivery in solid tumors.
https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-6-4
Dec 01, 2012 · Interstitial fluid pressure and velocity are used to show the details of drug delivery in a solid tumor, under an assumption that drug particles flow with the interstitial fluid. Drug delivery problems have been most extensively researched in spherical tumors, which have been the simplest to examine with the analytical methods.Author: M Soltani, Pu Chen
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