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https://www.researchgate.net/publication/7471431_Intelligent_hydrogels_for_the_oral_delivery_of_chemotherapeutics
Request PDF Intelligent hydrogels for the oral delivery of chemotherapeutics A novel approach toward improvements of oral chemotherapeutic formulations has evolved, which combines ...Author: Lev Bromberg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549393/
Polyelectrolyte complexes, such as chitosan–alginate, have been investigated as pH-responsive hydrogels for the oral delivery of peptides and proteins, such as hemoglobin . The complexation of chitosan and alginate results in decreased porosity, which is typical of alginate-only systems, and thus reduces drug leakage .Author: Lindsey A Sharpe, Adam M Daily, Sarena D Horava, Nicholas A Peppas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619027/
The local, oral delivery of chemotherapeutics to the colon maybe made possible by using pre-existing technology and biomaterials, by assembling them into novel structures and architectures that can elicit properties appropriate for the application at hand. 12–15 Hydrogels, a type of biomaterial, are three-dimensional networks, insoluble in aqueous environments due to physical and/or chemical crosslinks…Author: Cody A. Schoener, Heather N. Hutson, Nicholas A. Peppas
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.34532
pH‐responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics †Author: Cody A. Schoener, Heather N. Hutson, Nicholas A. Peppas
https://pubs.acs.org/doi/abs/10.1021/ie1008025
Complexation Hydrogels as Oral Delivery Vehicles of Therapeutic Antibodies: An in Vitro and ex Vivo Evaluation of Antibody Stability and Bioactivity. ... Intelligent recognitive systems in nanomedicine. ... pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics.Author: Daniel A. Carr, Marta Gómez-Burgaz, Mathilde C. Boudes, Nicholas A. Peppas
https://www.tandfonline.com/doi/abs/10.1517/17425247.2014.902047
Jul 21, 2014 · Introduction: Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent potential as oral therapeutic systems due to inherent biocompatibility, diversity of both natural and synthetic material options and tunable properties.Author: Lindsey A Sharpe, Adam M Daily, Sarena D Horava, Nicholas A Peppas
https://www.sciencedirect.com/science/article/pii/S246851941730263X
Focusing on drug delivery application, hydrogels are widely used in the development of intelligent systems for drug delivery . A lot of hydrogels, especially smart or intelligent hydrogels have been studied for use in drug delivery systems for delivery of various drugs ranging from low molecular weight drugs to macromolecular drugs such as peptides, growth factors and insulin [107] .Author: Mostafa Mahinroosta, Zohreh Jomeh Farsangi, Ali Allahverdi, Zahra Shakoori
https://www.sciencedirect.com/science/article/pii/S1359644616302562
As an alternative approach, localized chemotherapy can diminish the toxicity of systemic chemotherapy while providing a sustained release of the chemotherapeutics at the target tumor site. Therefore, injectable biodegradable hydrogels as drug delivery systems for chemotherapeutics have become a matter of importance.Author: Mohammad Norouzi, Bahareh Nazari, Donald W. Miller
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