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https://www.ncbi.nlm.nih.gov/pubmed/21909930
Utilizing integrins as delivery target, we have recently devised a strategy to target leukocytes termed Integrin-targeted and stabilized NanoParticles (I-tsNPs) that entrap high RNAi payloads and deliver them in a leukocyte-specific manner to induce robust gene silencing.Author: Noa Ben-Arie, Ranit Kedmi, Dan Peer
https://link.springer.com/protocol/10.1007/978-1-61779-166-6_29
Utilizing integrins as delivery target, we have recently devised a strategy to target leukocytes termed Integrin-targeted and stabilized NanoParticles (I-tsNPs) that entrap high RNAi payloads and deliver them in a leukocyte-specific manner to induce robust gene silencing.Author: Noa Ben-Arie, Ranit Kedmi, Dan Peer
https://www.researchgate.net/publication/51630607_Integrin-Targeted_Nanoparticles_for_siRNA_Delivery
Request PDF Integrin-Targeted Nanoparticles for siRNA Delivery Integrins are heterodimeric membrane glycoproteins composed of noncovalently associated α and β subunits.
https://www.sciencedirect.com/science/article/pii/S0168365915005738
Integrin-targeted nanoparticles are promising for the delivery of small interfering RNA (siRNA) to tumor cells or tumor endothelium in cancer therapy aiming at silencing genes essential for tumor growth.Author: Héloïse Ragelle, Stefano Colombo, Vincent Pourcelle, Kevin Vanvarenberg, Gaëlle Vandermeulen, Caroli...
https://www.ncbi.nlm.nih.gov/pubmed/25989603
Aug 10, 2015 · Integrin-targeted nanoparticles are promising for the delivery of small interfering RNA (siRNA) to tumor cells or tumor endothelium in cancer therapy aiming at silencing genes essential for tumor growth.Author: Héloïse Ragelle, Stefano Colombo, Vincent Pourcelle, Kevin Vanvarenberg, Gaëlle Vandermeulen, Caroli...
https://www.researchgate.net/publication/51843583_Integrin-Targeted_Stabilized_Nanoparticles_for_an_Efficient_Delivery_of_siRNAs_In_Vitro_and_In_Vivo
PDF Utilizing small interfering RNAs (siRNAs) to silence disease-associated genes holds promise as a potential therapeutic strategy. However, the... Find, read and cite all the research you ...
https://cancerres.aacrjournals.org/content/75/11/2316
Jun 01, 2015 · In the present study, we demonstrated ECO to be a versatile, safe, and effective siRNA delivery vehicle that forms stable RGD-targeted siRNA nanoparticles for systemic siRNA delivery, which silenced β3 integrin expression, and subsequently eliminated …Author: Jenny G. Parvani, Maneesh D. Gujrati, Margaret A. Mack, William P. Schiemann, Zheng-Rong Lu
https://link.springer.com/chapter/10.1007%2F978-1-4614-2305-8_8
Feb 01, 2012 · Winter PM, Caruthers SD, Zhang H, Williams TA, Wickline SA, Lanza GM (2008) Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis. ... Petkova V, Moore A (2007) In vivo imaging of siRNA delivery and silencing in tumors. Nat Med 13(3):372–377 CrossRef Google Scholar. 43.Author: Anita Gianella, Joanna C. Read, David P. Cormode, Zahi A. Fayad, Willem J. M. Mulder
https://www.nature.com/articles/nnano.2012.73
Nanoparticles are used for delivering therapeutics into cells. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and biodistribution, cell-specific internalization, excretion, toxicity and efficacy.Author: Hyukjin Lee, Hyukjin Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanou...
https://www.sciencedirect.com/science/article/pii/S1549963418305379
Nanoparticles for siRNA targeted delivery have long been studied as a particularly promising drug delivery vehicle. 9 Many of the targeted delivery systems, assembled by cationic polymers and amphiphilic compounds, have been used to directly introduce siRNA into the cancer cells.10, 11, 12 For example, Liu et al reported the multifunctional ...
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