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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086622/
Integrin targeted delivery of nanoparticle-carried chemotherapeutic agents. The third approach is to employ a nanoparticle-carried delivery system. Integrin targeted ligands, such as RGD peptides, can be coated on the surface of nanoparticle carrier system to selectively deliver chemotherapeutic agents to cancer cells or diseased tissues.Author: Zhaofei Liu, Fan Wang, Xiaoyuan Chen
https://www.tandfonline.com/doi/abs/10.1517/17425240903468696
Sep 20, 2013 · Importance of the field: Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiological activities to causing cellular dysfunction in diseased cells.Author: Zhe Wang, Wai-Keung Chui, Paul C Ho
https://mct.aacrjournals.org/content/15/6/1291
Jun 01, 2016 · The broad expression of integrins (including αvβ3, αvβ5, and α5β1) on tumor cells and their vasculature makes 2.5F-Fc an attractive tumor-targeting protein for drug delivery.Author: Nicolas V. Currier, Shelley E. Ackerman, James R. Kintzing, Rishard Chen, Maria Filsinger Interrante...
https://www.sciencedirect.com/science/article/pii/S0169409X15002860
Progress in integrin-targeted nano-delivery systems NP carriers can improve efficacy and/or tolerability of drugs in clinical use or under investigation, modifying solubility, improving ability to trespass biological barriers, preventing off-target degradation and metabolisation, and overcoming mechanisms of drug …Author: Daniela Arosio, Cesare Casagrande
https://www.ncbi.nlm.nih.gov/pubmed/28164756
OBJECTIVE: In this review, we summarize recent literature and patent applications in which integrin peptidic and peptidomimetic ligands were conjugated to chemotherapeutic agents both with stable or cleavable bonds to achieve tumor targeted drug delivery.Author: Daniela Arosio, Leonardo Manzoni, Cristina Corno, Paola Perego
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901818/
INTEGRIN α v β 3-TARGETED DRUG DELIVERY. To achieve an efficient concentration of therapeutics in the tumor, high dose of drugs are typically needed; this can lead to higher system toxicity in patients. For instance, targeted therapy using the specific binding ligand may significantly reduce the drug dose and hence the toxicity risk.Author: Zhaofei Liu, Zhaofei Liu, Fan Wang, Xiaoyuan Chen
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