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https://www.tandfonline.com/doi/full/10.1517/17425240903468696
Oct 03, 2008 · In this manner, the side effects of the cytotoxic drugs can be alleviated, to some extent, as well as lower doses of drugs being used for equivalent, if not better, therapeutic effect. Thus, the integrin targeted drug or gene delivery systems hold great promise for the treatment of diseases in human healthcare.Author: Zhe Wang, Wai-Keung Chui, Paul C Ho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315429/
The integrin receptor has been a star player in targeted drug delivery as clearly evidenced in recent literature. Integrin-targeted nanoparticles with diameters of 100–200 nm offer dual advantages of active-targeting and passive EPR-mediated effect which help enhance therapeutic efficacy by reducing drug dosage and often imparting selective tumor targeting ability.Author: Poulami Majumder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086614/
Integrin targeted lipoplexes. Cationic lipids have a long history as gene delivery carriers 47. Lipofectamine, DOTAP, Geneporter, DOTMA, to name a few, have already been commercialized and widely used 48-49. They form complexes with nucleic acids, also called lipoplexes, mainly through charge-charge interaction and hydrophobic forces 50.Author: Rudy L Juliano, Xin Ming, Osamu Nakagawa, Rongzuo Xu, Hoon Yoo
https://www.tandfonline.com/doi/abs/10.1517/17425240903468696
Sep 20, 2013 · Furthermore, nanoparticles with integrin targeting ligands for both drug and gene delivery, typically for antiangiogenesis and anticancer therapy, are highlighted and evaluated. What the reader will gain: This review sheds light on the future development of integrin targeted drug and/or gene delivery systems.Author: Zhe Wang, Wai-Keung Chui, Paul C Ho
https://www.researchgate.net/publication/41121330_Integrin_targeted_drug_and_gene_delivery
Furthermore, nanoparticles with integrin targeting ligands for both drug and gene delivery, typically for antiangiogenesis and anticancer therapy, are highlighted and evaluated.
https://www.researchgate.net/publication/51102698_Integrin_Targeted_Delivery_of_Gene_Therapeutics
Owing to their cancer-specific delivery and small size, these targeted nanoconjugates may become an effective drug delivery system for enabling molecularly targeted photodynamic therapy of cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086622/
Targeted delivery of chemotherapeutics is defined in the sense, that is, to maximize the therapeutic index of a chemotherapeutic agent by strictly localizing its pharmacological activity to …Author: Zhaofei Liu, Fan Wang, Xiaoyuan Chen
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1455841
May 23, 2018 · RGD peptide-based non-viral gene delivery vectors targeting integrin α vβ 3 for cancer therapy. Integrin α vβ 3 is restrictedly expressed on angiogenic blood vessels and tumour cells. It plays a key role in angiogenesis for tumour growth and metastasis.Author: Shuang Fu, Xiaodong Xu, Yu Ma, Shubiao Zhang, Shufen Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901818/
integrin α v β 3-targeted drug delivery To achieve an efficient concentration of therapeutics in the tumor, high dose of drugs are typically needed; this can lead to higher system toxicity in patients.Author: Zhaofei Liu, Zhaofei Liu, Fan Wang, Xiaoyuan Chen
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