Insulin Nanoparticles Oral Delivery

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Oral Insulin Delivery: How Far Are We?

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
    Mar 01, 2013 · Alginate has also been applied for oral insulin delivery. 56,64 Insulin encapsulated into alginate nanoparticles reduced the basal serum glucose levels by 40% after oral administration to diabetic rats. 56 In another study, insulin complexed with cationic β-cyclodextrin polymers in alginate/chitosan nanoparticles showed the ability of cationic β-cyclodextrin polymers to protect insulin …Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento

Nanoparticles enable oral insulin delivery in mice

    https://cen.acs.org/pharmaceuticals/drug-delivery/Nanoparticles-enable-oral-insulin-delivery/97/web/2019/11
    Nanoparticles enable oral insulin delivery in mice The particles help insulin, a peptide, to slip through the intestinal wall and into the bloodstream by Megha Satyanarayana

Potential of insulin nanoparticle formulations for oral ...

    https://www.ncbi.nlm.nih.gov/pubmed/28887133
    Oct 28, 2017 · Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles designed for oral administration of insulin. Firstly, the structure and physiological function of insulin are examined.Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass

Potential of insulin nanoparticle formulations for oral ...

    https://www.sciencedirect.com/science/article/pii/S0168365917308283
    Barriers to oral delivery of insulin nanoparticle formulation Effective oral delivery of insulin remains a significant challenge due to a few physiological barriers. The major barriers to oral administration of insulin can be classified as physical, chemical and enzymatic.Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass

Anionic nanoparticles enable the oral delivery of proteins ...

    https://www.nature.com/articles/s41551-019-0465-5
    Anionic nanoparticles increase intestinal permeability and enable the oral delivery of proteins, as shown with the delivery of insulin in healthy, hyperglycaemic, and diabetic mice.Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead

Oral Delivery of Insulin ScienceDirect

    https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
    Lipid-based nanoparticles such as liposomes and SLNs and inorganic nanoparticles like gold, silver, zirconium phosphate, etc. are nowadays extensively explored as carriers for oral delivery of insulin. Lipid nanoparticles enhance drug absorption in the GI tract, improve mucosal adhesion due to their small particle size, increase the GIT residence time, protect the loaded insulin from chemical and enzymatic degradation, and gradually release insulin …

Silica nanoparticles on the oral delivery of insulin

    https://www.researchgate.net/publication/326498925_Silica_nanoparticles_on_the_oral_delivery_of_insulin
    This challenging oral delivery of insulin can be achieved by promising silica nanoparticles (SNs), especially mesoporous silica nanoparticles (MSNs), with controllable morphology and high loading...

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