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https://www.sciencedirect.com/science/article/pii/S0378517309002968
Pharmaceutical Nanotechnology Insulin-micro- and nanoparticles for pulmonary delivery 1. Introduction. In spite of the many improvements in diabetes therapy,... 2. Materials and methods. The API in this study was recombinant human insulin... 3. Results and discussion. As every protein, insulin ...Author: Claudia Klingler, Bernd W. Müller, Hartwig Steckel
https://www.ncbi.nlm.nih.gov/pubmed/19446621
Jul 30, 2009 · The pulmonary application of insulin via oral inhalation turned out to be a promising option due to the large surface area and good vascularisation the lung is offering for the systemic delivery of peptides and proteins.Author: Claudia Klingler, Bernd W. Müller, Hartwig Steckel
https://www.researchgate.net/publication/24431555_Insulin-micro-_and_nanoparticles_for_pulmonary_delivery
A challenge for pulmonary delivery applications lies in the control over a size of insulin particles to be inhaled because the suitable aerodynamic diameter for such particles must be in the shows ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649680/
Dec 02, 2008 · Pure insulin microparticles produced through agglomeration of insulin nanoparticles may be a potential candidate for a pulmonary insulin formulation. The lack of penetration enhancers and other excipients in this formulation may reduce the occurrence of unforeseen side effects, thus making it potentially safer than existing alternatives.Author: Mark M. Bailey, Eric M. Gorman, Eric J. Munson, Cory J. Berkland
https://www.sciencedirect.com/science/article/pii/S0168365911005761
Chitosan (CS) is attractive for transmucosal drug delivery, e.g. pulmonary administration, owing to its reported low toxicity, biodegradability, biocompatibility and mucoadhesivity, as well as enhancement of macromolecules permeation , thus being extensively employed in the development of micro- and nanocarriers.Author: S. Al-Qadi, A. Grenha, D. Carrión-Recio, B. Seijo, C. Remuñán-López
https://www.researchgate.net/publication/23427096_Pure_Insulin_Nanoparticle_Agglomerates_for_Pulmonary_Delivery
Request PDF Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery Diabetes is a set of diseases characterized by defects in insulin utilization, either through autoimmune destruction ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-015-0136-y
Oct 24, 2015 · Due to the drawbacks of conventional injectable insulin, drugs have been modified through nanocarriers with targeting ligands for their selective and targeted delivery meant for oral and pulmonary delivery [22, 41]. Different nanoparticles developed to form stable and efficient insulin delivery system (Fig.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://erj.ersjournals.com/content/erj/44/3/765.full.pdf
Medical nanoparticles for next generation drug delivery to the lungs Sabine H. van Rijt 1, Thomas Bein2 and Silke Meiners Affiliations: 1Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum Mu¨nchen, Member of the German Center for Lung Research (DZL), Munich, Germany.Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
https://www.cell.com/heliyon/fulltext/S2405-8440(19)31154-5
May 15, 2019 · Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations.Author: Nazrul Islam, Isra Dmour, Mutasem O Taha
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/nanoparticle-insulin-drug-delivery-applications-and-new-aspects
Insulin is a key player in lowering blood glucose levels for type 1 diabetes and also required at later stages in type 2 diabetes patients. The widely accepted route for delivery of insulin is by parenteral administration but this delivery of insulin usually requires at least three or four daily insulin injections for good glycemic control.Author: Hatice Kübra Elçioğlu, Ali Demir Sezer
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