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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779563/
Background. Microneedles have previously been used to deliver insulin to animal models, but not in human subjects. This study tested the hypothesis that hollow microneedles can deliver insulin to modulate blood glucose levels in subjects with type 1 diabetes in a minimally invasive manner.Author: Jyoti Gupta, Eric Ian Felner, Mark R. Prausnitz
https://clinicaltrials.gov/ct2/show/results/NCT00837512
Insulin Delivery Using Microneedles in Type 1 Diabetes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
http://drugdelivery.chbe.gatech.edu/Papers/2009/Gupta%20Diabetes%20Technol%20Ther%202009.pdf
Minimally Invasive Insulin Delivery in Subjects with Type 1 Diabetes Using Hollow Microneedles Jyoti Gupta, B.S.,1,2 Eric I. Felner, M.D.,1,2 and Mark R. Prausnitz, Ph.D.1,3 Abstract Background: Microneedles have previously been used to deliver insulin to animal models, but not in human
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131988/
In this report, we present the first peer-reviewed study in human subjects to test the hypothesis that intradermal insulin infusion using microneedles leads to more rapid PK, improved postprandial glycemic control, and less pain than subcutaneous catheter-based infusion in subjects with type 1 diabetes.Author: Jyoti Gupta, Eric Ian Felner, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S1773224715000714
Recently, MNs have been widely studied for transdermal delivery of insulin. This review describes recent and future developments for MN technology and the delivery strategies of insulin using MN, including the latest type of MN design, challenges and potential safety aspects.Author: Song Xie, Zijing Li, Zongqin Yu
https://www.liebertpub.com/doi/10.1089/dia.2010.0204
Mar 27, 2011 · Background: This study compared the pharmacokinetics, postprandial glycemic response, and pain associated with intradermal lispro insulin delivery using a microneedle with that of a conventional catheter. Subjects and Methods: Five subjects with type 1 diabetes were administered a bolus infusion of lispro insulin using a 9-mm-long subcutaneous catheter (control treatment) and a 0.9 …Author: Jyoti Gupta, Eric Ian Felner, Mark R. Prausnitz
http://drugdelivery.chbe.gatech.edu/Papers/2011/Gupta%20Diabetes%20Technol%20Ther%202011.pdf
Rapid Pharmacokinetics of Intradermal Insulin Administered Using Microneedles in Type 1 Diabetes Subjects Jyoti Gupta, Ph.D.,1,2 Eric I. Felner, M.D., MSCR,1,2 and Mark R. Prausnitz, Ph.D.2,3 Abstract Background: This study compared the pharmacokinetics, postprandial glycemic response, and pain associated with intradermal lispro insulin ...
https://www.researchgate.net/publication/24443927_Minimally_Invasive_Insulin_Delivery_in_Subjects_with_Type_1_Diabetes_Using_Hollow_Microneedles
This study was carried out in two adults with type 1 diabetes and evaluated bolus delivery of lispro insulin using a hollow microneedle compared to a catheter infusion set (9 mm).
https://www.researchgate.net/publication/275466516_Microneedles_for_transdermal_delivery_of_insulin
Diabetes is one of the leading lethal diseases and insulin is the most effective medicine to control BGL in type 1 diabetic patients. Transdermal delivery of insulin has been regarded as an ...
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