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https://www.sciencedirect.com/science/article/pii/S1773224715000714
Microneedles have been widely studied for transdermal delivery of insulin. In this review, we describe the recent and emerging progress in MN technologies for insulin delivery, which suggest that MNs may provide a powerful new approach for transdermal insulin delivery.Author: Song Xie, Zijing Li, Zongqin Yu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779563/
The study first determined the minimum insulin delivery depth by administering insulin from microneedles inserted 1, 3.5, and 5 mm into the skin of fasting subjects and then assessed the efficacy of insulin delivery from microneedles inserted 1 mm into the skin to reduce postprandial glucose levels.Author: Jyoti Gupta, Eric Ian Felner, Mark R. Prausnitz
http://drugdelivery.chbe.gatech.edu/Papers/2004/Martanto%20Pharm%20Res%202004.pdf
Transdermal Delivery of Insulin Using Microneedles in Vivo Wijaya Martanto, 1Shawn P. Davis, Nicholas R. Holiday,1 Jenny Wang,2 Harvinder S. Gill,2 and Mark R. Prausnitz1,2,3 Received November 26, 2003; accepted January 11, 2004
http://drugdelivery.chbe.gatech.edu/Papers/2009/Gupta%20Diabetes%20Technol%20Ther%202009.pdf
Minimally Invasive Insulin Delivery in Subjects with Type 1 Diabetes Using Hollow Microneedles Jyoti Gupta, B.S.,1,2 Eric I. Felner, M.D.,1,2 and Mark R. Prausnitz, Ph.D.1,3 Abstract Background: Microneedles have previously been used to deliver insulin to animal models, but not in human
https://www.sciencedirect.com/science/article/pii/S0142961219308518
(E) Comparisons of the release profiles of insulin between the PCM and DMN groups using the implantation system. The PCM group showed a retardation of transdermal insulin delivery (n = 4, mean ± SEM). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
https://www.sciencedirect.com/science/article/pii/S0169409X18300504
Introducing microneedles (MNs) to insulin delivery is promising to pave the way for modulating glucose level noninvasively of diabetes patients, as which born to be painless, easy to handle and no need of any power supply. In this work, we review the process of insulin delivery systems (IDSs) based on MN technology in terms of two categories ...Author: Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin’s barrier properties prevent insulin permeation at useful levels.We investigated whether microdermabrasion ...Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://clinicaltrials.gov/ct2/show/NCT00837512
Insulin Delivery Using Microneedles in Type 1 Diabetes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
https://www.liebertpub.com/doi/10.1089/dia.2008.0103
May 21, 2009 · Methods: This study was carried out in two adults with type 1 diabetes and evaluated bolus delivery of lispro insulin using a hollow microneedle compared to a catheter infusion set (9 mm). The study first determined the minimum insulin delivery depth by administering insulin from microneedles inserted 1, 3.5, and 5 mm into the skin of fasting ...Author: Jyoti Gupta, Eric Ian Felner, Mark R. Prausnitz
https://en.wikipedia.org/wiki/Microneedle_drug_delivery
This early paper sought to explore the possibility of using microneedles in the future for vaccination. Since then researchers have studied microneedle delivery of insulin, vaccines, anti-inflammatories, and other pharmaceuticals. In dermatology, microneedles are used for scarring treatment with skin rollers.
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