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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107450/
May 28, 2013 · Injectable Nano-Network for Glucose-Mediated Insulin Delivery. ... Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose ...Author: Zhen Gu, Alex A. Aimetti, Qun Wang, Tram T. Dang, Yunlong Zhang, Omid Veiseh, Hao Cheng, Robert S. L...
https://pubs.acs.org/doi/abs/10.1021/nn400630x
An artificial “closed-loop” system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network.Author: Zhen Gu, Alex A. Aimetti, Qun Wang, Tram T. Dang, Yunlong Zhang, Omid Veiseh, Hao Cheng, Robert S. L...
https://www.ncbi.nlm.nih.gov/pubmed/23638642
May 28, 2013 · An artificial "closed-loop" system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network.Author: Zhen Gu, Alex A. Aimetti, Qun Wang, Tram T. Dang, Yunlong Zhang, Omid Veiseh, Hao Cheng, Robert S. L...
http://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1087&context=cbe_pubs
Injectable Nano-Network for Glucose-Mediated Insulin Delivery Abstract Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial “closed-loop” system able to mimic pancreas activity and release insulin in response to
https://www.researchgate.net/publication/236612772_Injectable_Nano-Network_for_Glucose-Mediated_Insulin_Delivery
Request PDF Injectable Nano-Network for Glucose-Mediated Insulin Delivery Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world.
https://dspace.mit.edu/openaccess-disseminate/1721.1/91254
injectable polymeric nanoparticle-cross-linked network (designated nano-network) capable of glucose-mediated insulin delivery. Using chemically modified dextran (designated m-dextran) as an acid-degradable and biocompatible matrix material, we have demonstrated that the resulting nano-network can be utilized for glucose-regulated insulin delivery.
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