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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · The STACCATO ® is a novel breath-actuated inhalation delivery system, which uses heat to vaporize a thin film of the drug, which later condenses in the lungs into droplets or particles depending on the nature of the drug.78 In that case, the drug is dissolved in volatile solvent/solvent mixture which is sprayed over a metal substrate such as zinc halides. The best drug candidates for such systems …Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
https://www.ondrugdelivery.com/overview-dry-powder-inhalation-systemic-drug-delivery/
Interest is growing in the treatment of systemic diseases using active pharmaceutical ingredients (APIs) administered via inhalation, a method especially applicable to the delivery of biomolecules. Inhalation therapy in its various forms has been used for hundreds of years, 1 used mainly to treat or alleviate conditions of the lungs, asthma and chronic obstructive pulmonary disease (COPD).
https://www.ncbi.nlm.nih.gov/pubmed/16551214
Generally, the deposition of small molecules in the "deep lung" leads to high absorption rates, making the inhalation delivery attractive for drugs with intended rapid onset of action. Many therapeutics, especially peptides and proteins, that cannot be delivered systemically non-invasively, are absorbed with various degrees of systemic bioavailability via inhalation.Author: Igor Gonda
https://www.mannkindcorp.com/Collateral/Documents/English-US/Innovation%20In%20Drug%20Delivery%20by%20Inhalation.pdf
for inhaled drug delivery. Going forward, systemic delivery by inhalation will have a dramatic impact on the market as more active agents are shown to benefit from this route of administration. However, the real impact will be realised when patients are given the opportunity to self-administer therapies in easy-to-use, patient-friendly delivery systems. MannKind’s
https://www.aarc.org/wp-content/uploads/2018/03/aersol-guides-for-hcp.pdf
tion. Medication delivery by inhaled aerosols has significant advantages over systemic drug delivery and includes: • Select treatment of the lungs through direct deposi-tion of medication to airway receptor sites allowing for lower medication dosages to achieve the desired therapeutic effect • Rapid onset of action of bronchodilation medication
https://www.atsjournals.org/doi/full/10.1513/pats.200409-049TA
Dec 01, 2004 · One of the most promising applications of inhalation technologies is the systemic delivery of therapeutic peptides and proteins that must otherwise be given by injection . For reasons that are not well understood, the deep lung provides higher bioavailability for macromolecules than any other noninvasive port of entry . Although inhaled peptides and proteins are not yet commercially available for patients to treat systemic diseases…Author: John S. Patton, C. Simone Fishburn, Jeffry G. Weers
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Direct delivery of chemotherapeutic agents via inhalation guarantees localized (regional) administration of anticancer agents within the lungs, thus escaping from the systemic dilution, increasing the chances of their accumulation within tumor cells rather than normal cells, exerting their cytotoxic activity at doses lower than the corresponding systemic delivery which in turns minimizes dose-limiting toxicities [14].
https://www.vero-biotech.com/
Inhaled Nitric Oxide Delivery Inhaled Nitric Oxide (NO) has the potential to benefit patients, from neonates to adults with a range of cardiopulmonary conditions characterized by pulmonary hypertension – whether the patients are in critical care hospital settings, chronic care facilities, or even in the home.
https://www.sciencedirect.com/science/article/pii/S1471489217300176
Inhalation of flecainide delivered the drug into the systemic circulation within 1–3 min, yielding venous plasma levels sufficient to elicit an electrophysiological effect. There is one caveat; flecainide has previously been associated with high lung accumulation and drug-induced interstitial lung disease [ …Author: Wilbur de Kruijf, Carsten Ehrhardt
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