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https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · To investigate our ability to predict in vivo siRNA delivery potency without any biological testing, we custom synthesized a small second-generation library of …Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
Technology exploiting this phenomenon may be used for functional genomics and target validation, and is being developed for therapeutic purposes. Because of its potency, siRNA has rapidly become the most widely used trigger for inducing gene knockdown in cultured mammalian cells. siRNA delivery in vivo is a more challenging task.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
May 05, 2010 · To improve the evaluation of siRNA delivery in vivo, we tailored an approach that quantifies the small RNAs residing in the RISC from the tissues of rodents and monkey. Application of our approach to preclinical animal studies yielded quantitative insights into the in vivo efficiency of siRNA delivery and the mechanism of RNA silencing.Author: Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207430/
Dysfunctional endothelium contributes to more disease than any other tissue in the body. Small interfering RNAs (siRNAs) have the potential to help study and treat endothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA delivery has so far remained challenging. Here we show that polymeric nanoparticles made of low molecular weight polyamines and lipids ...Author: James E. Dahlman, Carmen Barnes, Omar F. Khan, Aude Thiriot, Siddharth Jhunjunwala, Taylor E. Shaw, ...
https://www.nature.com/articles/nnano.2012.73
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Hyukjin Lee 1,4, Abigail K. R. Lytton-Jean 1, Yi Chen 1, Kevin T. Love 1, Angela I. Park 1,Author: Hyukjin Lee, Hyukjin Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanou...
http://www.invivotransfection.com/
In Vivo Transfection In Vivo Background . With modern genetic techniques allowing scientists to identify the link between genes and diseases, there is an enormous emphasis on determining ways to alter the function of a gene in vivo.Strategies to treat these diseases include delivering an alternate gene to the cell, replacing the defective gene or silencing the defective gene using RNAi or ...
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
for in vitro and in vivo siRNA delivery, and their knockdown (KD) efficiency in selected in vitro and in vivo models. Of note, we have listed only those publications that reported the in vivo .
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201903637
With regard to in vivo siRNA delivery, the fusogenic porous silicon nanoparticles (FNPs) demonstrated effective use of targeting peptides to induce siRNA‐mediated gene silencing in multiple cell targets within a single mouse model. 99 Figure 8 shows a significant example of the versatility of the approach, where three different targeting ...Author: Byungji Kim, Ji‐Ho Park, Michael J. Sailor
https://www.hindawi.com/journals/jdd/2017/4070793/
siRNA stabilized for in vivo applications is filtered and reabsorbed in the renal proximal tubule (PT), reducing mRNA expression transiently. Prior siRNA efforts have successfully prevented upregulation of mRNA in response to injury. We proposed reducing constitutive gene and protein expression of LRP2 (megalin) in order to understand its molecular regulation in mice.Author: Michael T. Eadon, Ying-Hua Cheng, Takashi Hato, Eric A. Benson, Joseph Ipe, Kimberly S. Collins, Tho...
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