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http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
Co-delivery of siRNA with reporter vectors by hydrodynamic tail vein injection provides a starting point for researchers interested in performing RNAi experiments in the liver. There is a need to develop alternative techniques to enable specific delivery to other organs using normal low-pressure injection conditions.
http://www.invivotransfection.com/
In Vivo Transfection In Vivo Background . With modern genetic techniques allowing scientists to identify the link between genes and diseases, there is an enormous emphasis on determining ways to alter the function of a gene in vivo.Strategies to treat these diseases include delivering an alternate gene to the cell, replacing the defective gene or silencing the defective gene using RNAi or ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
May 05, 2010 · In vivo quantification of Ago2-associated siRNA and target gene silencing. To further validate our method and gain quantitative insights into siRNA delivery in vivo, we performed a mouse study measuring both gene silencing and Ago2-associated siRNA strand levels from tissue samples.Author: Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The resulting siRNA–PPI nanoparticles (100–150 nm) showed specific intracellular delivery, release of siRNA in the cytoplasm, and efficient gene silencing in vivo . Over the last decade, cyclodextrin-containing cationic polymers and dendrimers have received growing attention as …Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
Advirna is developing innovative solutions for oligonucleotide delivery to cells ex-vivo and in-vivo. Our technology platform - self-deliverable RNAi technology (sdRNAi) allows efficient knockdown of genes in hard-to-transfect cell lines ex vivo and in vivo using RNAi interference. sdRNAi technology is based on the deep chemical modification of siRNAs and allows efficient delivery of RNAi into ...
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Exosomes are promising tools for drug delivery across different biological barriers. Here we show how exosomes derived from cultured cells can be …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.thermofisher.com/us/en/home/life-science/rnai/introduction-to-in-vivo-rnai/invivofectamine-reagent.html
Breakthrough in vivo transfection reagent. Invivofectamine 3.0 Reagent is a breakthrough reagent for in vivo RNAi delivery, with greatly improved performance and up to 85% knockdown achieved using microgram levels of siRNA.View the Invivofectamine 3.0 FAQs. Easy to use—siRNA complexes are ready to deliver in just a few steps; Effective, targeted knockdown—up to 85% knockdown observed …
https://www.pnas.org/content/104/32/12982
Aug 07, 2007 · Abstract. Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a therapeutic modality. Hepatocytes, the key parenchymal cells of the liver, are a particularly attractive target cell type for siRNA delivery given their central role in several infectious and metabolic disorders.Author: David B. Rozema, David L. Lewis, Darren H. Wakefield, So C. Wong, Jason J. Klein, Paula L. Roesch, S...
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery. ... The challenges in in vivo RNAi and materials design requirements to overcome them are reviewed. Recent trends ...
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