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https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201600418
This review provides an introduction to the in vivo barriers that need to be addressed by siRNA delivery systems. We also discuss the progress up to the most effective and clinically advanced siRNA delivery systems including liposomal, polymeric and siRNA conjugate delivery systems, as well as their design to overcome the challenges.Author: William Ho, Xue-Qing Zhang, Xiaoyang Xu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Readers are referred to the excellent reviews outlining the physical and immunologic barriers to siRNA delivery to the eye, skin, lung, and brain (26 – 29). Systemic delivery, e.g., intravenous injection, of siRNA poses significantly greater challenges.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
This review will focus on current challenges and strategies for delivery of miRNAs In vivo through local and systemic or targeted administration. The strategies employed in In vivo miRNA delivery for cancer therapy are summarized in Table 1.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1742-4658.2010.07904.x%4010.1002/%28ISSN%291742-4658%28CAT%29FreeReviewContent%28VI%29Reviews1011
review, major factors in determining overall RNAi ... Moreover, up-to-date progress in achieving efficient and targeted siRNA delivery in vivo, particularly by overcoming multiscale hurdles using novel siRNA carriers, is discussed. Challenges in RNAi in vivo Design and in vivo delivery of siRNA There are multiple key considerations in order toAuthor: Min Suk Shim, Young Jik Kwon
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201903637
Sep 30, 2019 · The primary obstacle to realization of RNAi therapy has been the delivery of oligonucleotide payloads. Therefore, the main aims is to identify and describe key design features needed for nanoscale vehicles to achieve effective delivery of siRNA‐mediated gene silencing agents in vivo.Author: Byungji Kim, Ji‐Ho Park, Michael J. Sailor
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · Hassler, M. R. et al. Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Res. 46 , 2185–2196 (2018).Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
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