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https://www.pharmatutor.org/articles/review-implantable-drug-delivery-system
Therefore, drug delivery systems were developed to optimize the therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development.
https://www.sciencedirect.com/science/article/pii/B9780128136652000132
The concept of implantable drug delivery systems (IDDSs) in modern medicine may be traced to Deansby and Parkes who, in 1938, subcutaneously (SC) implanted compressed pellets of crystalline estrone to study their effect upon castrated male chickens (Kleiner et al., 2014).Folkman and Long pioneered implantable formulations, with drug release rates controlled by a polymeric membrane, in the 1960s.Author: Anoop Kumar, Jonathan Pillai
https://www.tandfonline.com/doi/abs/10.3109/03639049109026629
Dec 19, 2006 · AbstractOrigins of rate controlled implantable drug delivery dates back to 1964 when silicone implants were used to prolong a drug effect. Despite much activity in the years since 1964, the progress to a safe, effective and acceptable implant system(s) has been slow. The critical factors in implant research which need to be addressed include: erodibility, reproducibility, lack of irritation ...Author: M. Danckwerts, A. Fassihi
https://www.researchgate.net/publication/319327771_Implantable_drug_delivery_systems_An_Overview
Implantable drug delivery systems offer physicians the choice of precision delivery, either locally or into systemic circulation, while guaranteeing optimal dosing over the course of treatment.The ...
https://www.sciencedirect.com/science/article/pii/S0168365914000728
8. Modeling of implantable and insertable drug delivery systems. Research into IDDS has been aided by the development of mathematical models describing drug delivery rate kinetics and other aspects of system functionality. In the early 1960s T. Higuchi presented the now classic “Higuchi model” .Author: Lothar W. Kleiner, Jeremy C. Wright, Yunbing Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576846/
The implementation of micro- and nano-technologies for implantable drug-delivery systems offer new possibilities in achieving control of in vivo drug release. Reservoir-based devices The simplest miniaturized implantable drug-delivery systems feature a reservoir with a membrane that controls the onset or rate of drug administration.Author: Ellis Meng, Tuan Hoang
https://www.researchgate.net/publication/266504147_Implantable_Drug_Delivery_System_A_Review
Implantable Drug Delivery System: A Review. ... Implantable drug delivery systems (IDDS) are an example of such systems available for therapeutic use. ... to the controlled dispersed-drug release ...
https://www.ncbi.nlm.nih.gov/pubmed/2229447
Drug delivery systems. 4. Implants in drug delivery. Ranade VV(1). Author information: (1)Action Medical Marketing Co. Libertyville, Illinois. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development.Author: Vasant V. Ranade
https://promedmolding.com/implantable-drug-delivery-devices-overview/
Dec 18, 2017 · As with all implantable devices, key materials considerations for use in drug delivery include biocompatibility, stability and durability (except in the case of biodegradable drug delivery systems), and the ability of the material to control release of the active pharmaceutical ingredient (API).
http://sphinxsai.com/2012/pharm/PHARM/PT=40(280-292)JM12.pdf
were introduced. As time progressed, there was a need for delivery systems that could maintain a steady release of drug to the specific site of action. Therefore, drug delivery systems were developed to optimize the therapeutic properties of drug products and render them more safe, effective, and reliable. Implantable drug delivery systems
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