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https://www.sciencedirect.com/science/article/pii/S0168365904003128
Hydrotropic polymer micelle system has been developed for delivery of poorly water-soluble drugs such as paclitaxel. Hydrotropic polymers based on N,N-diethylnicotinamide were synthesized and used as a hydrophobic block for constructing amphiphilic block copolymers. The hydrotropic block copolymers self-assembled to form micelles in aqueous media.Author: Kang Moo Huh, Sang Cheon Lee, Yong Woo Cho, Jaehwi Lee, Jae Hyun Jeong, Kinam Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288664/
Mar 03, 2008 · A New Hydrotropic Block Copolymer Micelle System for Aqueous Solubilization of Paclitaxel Kang Moo Huh , a, * Hyun Soo Min , a Sang Cheon Lee , b Hong Jae Lee , b Sungwon Kim , c and Kinam Park c a Department of Polymer Science and Engineering, Chungnam National University, Daejeon 305-764, South KoreaAuthor: Kang Moo Huh, Hyun Soo Min, Sang Cheon Lee, Hong Jae Lee, Sungwon Kim, Kinam Park
https://www.researchgate.net/publication/8138915_Hydrotropic_polymer_micelle_system_for_delivery_of_paclitaxel
Hydrotropic polymer micelle system has been developed for delivery of poorly water-soluble drugs such as paclitaxel.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695849/
Dec 18, 2008 · Hydrotropic polymers (HPs) and their micelles have been recently developed as vehicles for delivery of poorly water-soluble drugs, such as paclitaxel (PTX), by oral administration. The release of PTX from HP micelles, however, was slow and it took more than a day for complete release of the loaded PTX.Author: Sungwon Kim, Ji Young Kim, Kang Moo Huh, Ghanashyam Acharya, Kinam Park
https://www.sciencedirect.com/science/article/pii/S0168365907006311
Even in the previous study on the hydrotropic PEG-b–P(2-VBODENA) polymer micelle, the very high loading content could be obtained via a dialysis method, but with use of acetonitrile as a solvent to dissolve PTX and the polymer. Because such a high loading content was considered as a result of combined effects of hydrotropy and micellization, each effect could not be evaluated.Author: Kang Moo Huh, Hyun Soo Min, Sang Cheon Lee, Hong Jae Lee, Sungwon Kim, Kinam Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532792/
Although the hydrotropic polymer micelles have higher paclitaxel loading up to 37%, hydrotropic polymer micelles with only 20% and 25% paclitaxel loading were used to compare the efficacy with that of the PLA-PEG micelle. At equivalent paclitaxel loading of 25%, hydrotropic polymer micelles were substantially more effective.Author: Sang Cheon Lee, Kang Moo Huh, Jaehwi Lee, Yong Woo Cho, Raymond E. Galinsky, Kinam Park
https://www.sciencedirect.com/science/article/pii/S0168365908003763
Hydrotropic polymers (HPs) and their micelles have been recently developed as vehicles for delivery of poorly water-soluble drugs, such as paclitaxel (PTX), by oral administration. The release of PTX from HP micelles, however, was slow and it took more than a day for complete release of the loaded PTX.Author: Sungwon Kim, Ji Young Kim, Kang Moo Huh, Ghanashyam Acharya, Kinam Park
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