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https://www.future-science.com/doi/10.4155/tde.12.39
Hydroxyapatite nanoparticles are deemed a feasible candidate and possess many characteristics desired of an ideal gene vector. Current fabrication techniques can readily synthesize hydroxyapatite particles in the nanometer range; however, these particles suffer from extensive aggregation and heterogeneity, mainly in size, shape and surface charge, which render them inappropriate for gene-therapy application.Author: Thi Ngoc Tram Do, Wing-Hin Lee, Ching-Yee Loo, Alexander V Zavgorodniy, Ramin Rohanizadeh
https://www.researchgate.net/publication/230571494_Hydroxyapatite_nanoparticles_as_vectors_for_gene_delivery
The synthesized HAP is also of nano-sized level. Nano-hydroxyapatite argininefunctionalized and doped with rare earth such as Tb3+, is suitable for the application of gene delivery as a gene carrier.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747848/
The rise of nanotechnology has provided new methods and tools for the study of gene carriers.20 Among these, calcium phosphate nanoparticles have emerged as a potential vector for nonviral gene delivery.21–23 Hydroxyapatite [Ca 10 (OH) 2 (PO 4) 6, HA], a ceramic compound with a composition similar to that of mammalian bone and the dentin ...Author: Yan Chen, Lifang Yang, Suping Huang, Zhi Li, Lu Zhang, Jiang He, Zhijie Xu, Liyu Liu, Ya Cao, Lunqua...
https://www.intechopen.com/books/hydroxyapatite-advances-in-composite-nanomaterials-biomedical-applications-and-its-technological-facets/gene-delivery-by-hydroxyapatite-and-calcium-phosphate-nanoparticles-a-review-of-novel-and-recent-app
For the uptake of macromolecules or nanoparticles, endocytosis as a frequent methodology can internalize non-viral gene delivery vectors . Endocytosis can be defined as the penetration of the cell membrane which is followed by the incorporation into an intracellular vesicle [ 25 ].Author: Feray Bakan
http://research.sabanciuniv.edu/35722/1/bookchapter_FB.pdf
For the uptake of macromolecules or nanoparticles, endocytosis as a frequent methodology can internalize non-viral gene delivery vectors [24 þï1¢11111111111 11 followed by the incorporation into an intracellular vesicle [ 25 ].
https://www.researchgate.net/publication/323179319_Gene_Delivery_by_Hydroxyapatite_and_Calcium_Phosphate_Nanoparticles_A_Review_of_Novel_and_Recent_Applications
Gene Delivery by Hydroxyapatite and Calcium Phosphate Nanoparticles: A Review of Novel and Recent Applications Chapter (PDF Available) · February 2018 with 320 Reads How we measure 'reads'
https://www.spandidos-publications.com/10.3892/ijo.2015.2918/abstract
Hydroxyapatite nanoparticles modified by branched polyethylenimine are effective non-viral vectors for siRNA transfection of hepatoma cells in vitro ... (GAPDH) in BEL-7402 cells, which supports that MnHAP might be a promising non-viral vector for biomedical research and gene delivery. View Figures ... Jiang, Q., Luo, B., Li, G."Hydroxyapatite ...Author: Xiao-Lin Xu, Hai-Yun Yang, Bing Ou, Shu-Dong Lin, Huan Wu, Wang He, Qiong-Chao Jiang, Bao-Ming Luo, ...
https://www.sciencedirect.com/science/article/pii/S1003632615636299
In recent years, hydroxyapatite nanoparticles (HAp) have attracted considerable attention as new candidates of nonviral vectors for gene therapy due to its excellent properties: 1) biodegradability and biocompatibility, 2) protection of DNA from degradation, 3) ease of synthesis and surface modification to strong interaction with their payload, 4) capability of targeted delivery to specific organs or cells and …Author: Guo-hui Wang, Yan-zhong Zhao, Juan Tan, Shai-hong Zhu, Ke-chao Zhou
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131585/
Gene delivery techniques efficiently introduce a gene of interest in order to express its encoded protein in a suitable host or host cell. Currently, there are three primary gene delivery systems that employ viral vectors (retroviruses and adenoviruses), nucleic acid electroporation, and nucleic acid transfection.Author: Daisuke Kami, Shogo Takeda, Yoko Itakura, Satoshi Gojo, Masatoshi Watanabe, Masashi Toyoda
https://www.sciencedirect.com/science/article/pii/S037851730400540X
pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery ... Mn 2+, Ba 2+, etc. have never been explored as non-viral vectors for gene delivery although some works have been reported on the in vitro use of silica nanoparticles (Luo et al., 2004 ... The diffractograms obtained for void and DNA loaded ...Author: Savita Bisht, Gajadhar Bhakta, Susmita Mitra, Amarnath Maitra
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