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https://www.sciencedirect.com/science/article/pii/B9780128040195000128
The use of polymeric particles for vaccine delivery has a long history, and if the area is to see some eventual success, it will be because scientists are able to embrace and understand the overall lessons, including those from both older and newer publications, as this is how science usually advances.Author: P. Malyala, D.T. O'Hagan
https://www.sciencedirect.com/science/article/pii/B9780323399814000105
Polymer-based nanoparticles constitute a promising delivery system for vaccine antigens and adjuvants, benefiting from numerous properties that promote an efficient priming of the immune response. Next to that, morphology and composition of nanoparticles mimicking key features of pathogens provide them with intrinsic adjuvant properties.Author: L. Lambricht, C. Peres, H. Florindo, V. Préat, G. Vandermeulen
https://www.researchgate.net/publication/41039345_Polymeric_particles_in_vaccine_delivery
Polymeric particles in vaccine delivery. The tremendous power of the particulate vaccine delivery system has only recently been recognized and employed strategically in vaccine design. The entrapment of antigen in particles clearly alters its acquisition and processing by antigen presenting cells and ensuing adaptive immunity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162053/
Dec 01, 2013 · PLGA is a FDA approved biodegradable and biocompatible synthetic polymer which has been extensively studied as a vaccine delivery system in preclinical settings as well as having been used as sutures and for controlled drug delivery in the biomedical arena. 4, 19-28 PLGA particles as vaccine carriers offer multiple advantages over many other vaccine delivery systems. For example, PLGA is a synthetic polymer …Author: Vijaya B Joshi, Sean M Geary, Aliasger K Salem
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
Polymers in solid particulate vaccine delivery. Biodegaradable polymers such as PLGA, previously used as surgical implant and suture material is now being exploited for matrix antigen delivery. PLGA microspheres are rapidly taken up by M-cells and translocated towards …
https://www.sciencedirect.com/science/article/pii/S0928493119320661
Electrospray generates particles from many polymers for drug and vaccine delivery, gene therapy and tissue engineering. These particles can be used to treat cancer, pathogenic infections, inflammation and to prophylactically prevent infectious diseases.Author: Rebeca T. Steipel, Matthew D. Gallovic, Cole J. Batty, Eric M. Bachelder, Kristy M. Ainslie
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964737/
Oct 29, 2015 · One of the most remarkable features of PLGA polymers, as a unique vaccine delivery system, is the possibility of tuning the physico-chemical properties of the PLGA polymer in order to achieve the desired release profile dictated by the target product profile. 15,22 Most researchers believe that PLGA degradation is solely driven by a hydrolytic mechanism that exclusively happens by hydrolysis of ester linkages in polymer …Author: Mojgan Allahyari, Elham Mohit
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607064/
Mar 25, 2013 · Hydrophilic polysaccharide polymers are also good candidates for vaccine delivery with both dextran and chitosan being chosen for preparing NPs. Much attention has focused on chitosan NPs because of the biocompatibility of chitosan, its biodegradability into non-toxic products in vivo and its ability to open up tight junctions between epithelial cells (Sonaje et al., 2012 ).Author: Anthony E. Gregory, Richard Titball, Diane Williamson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365085/
Jan 23, 2015 · They then show how co-delivery of autoantigen and B7 pathway modulators suppresses EAE . Norian and colleagues report on a therapeutic vaccine involving tumor lysate-loaded MPs that reduce spontaneous metastases in a murine breast cancer model . There is currently no cure for metastatic breast cancer, and available therapies are often ...Author: Aliasger K. Salem
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