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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438887/
The majority of responsive polymers for drug delivery can be broadly categorized as hydrogels, micelles, polyplexes, or polymer-drug conjugates, which are covered in more detail below. Hydrogels are hydrophilic (co)polymeric networks capable of imbibing large amounts of water or biological fluids (38).Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://link.springer.com/chapter/10.1007/978-1-4614-0881-9_3
Sep 27, 2011 · Over the recent years, the use of hydrophobic polymers for drug delivery applications has dramatically increased. These materials offer particular promise for controlled/sustained-drug release, thereby enhancing the pharmacological effects of the drug.Author: Osama A. Abu-Diak, Gavin P. Andrews, David S. Jones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://pubs.acs.org/doi/10.1021/bm4017594
Engineered silk-elastin-like protein polymers, triggered by hydrophobic molecules, assembled into nanoparticles with potential for use for the delivery of hydrophobic drugs. A major advantage of SELPs system is that nanoparticles, fully biocompatible, can be fabricated and loaded with an all-aqueous process under mild conditions, which is important for the encapsulation of unstable drugs.Author: Xiao-Xia Xia, Ming Wang, Yinan Lin, Qiaobing Xu, David L. Kaplan
https://www.sciencedirect.com/topics/materials-science/hydrophobic-polymer
Hydrophobic drugs can typically be dissolved in hydrophobic polymers like PCL, PLGA, PLA, etc. using common solvents such as dichloromethane (DCM) prior to electrospinning. In exceptional cases, such as ginsenoside-Rg3 (Rg3) drug, the drug may first be dissolved in a small amount of solvent such as hexafluoro-2-propanol (HFIP) before mixing with the polymer solution.
https://www.sigmaaldrich.com/technical-documents/articles/materials-science/poly-amino-acid-block-copolymers.html
When used as drug delivery vehicles, amphiphilic diblock copolymers generally self-assemble into classic spherical polymeric micelles upon exposure to a selective solvent such as water (Figure 2A). In most cases, the hydrophobic segment packs tightly to avoid contact with the water and the hydrophilic segment readily solubilizes to form a shell or corona around the hydrophobic core.
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