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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064722/
1. Introduction. Hydrodynamic delivery is one of non-viral methods developed originally for intracellular gene delivery but later found applicable to delivery of other macromolecules such as oligo nucleotides, RNA, proteins, and the compounds that are not permeable to cell membrane.Author: Barbara Bonamassa, Li Hai, Dexi Liu
https://www.sciencedirect.com/science/article/pii/S1525001616327198
Hydrodynamic gene delivery has been shown to be able to promote both humoral- and cell-based immunity in animals in a gene dependent manner. Hydrodynamic gene delivery generates much more gene product than does the commonly used method of intramuscle injection of plasmid DNA.Author: Takeshi Suda, Dexi Liu
https://www.ahajournals.org/doi/10.1161/01.CIR.0000160348.75918.CA
Background— Interleukin-1 (IL-1) is a powerful and important cytokine in myocarditis. The purpose of this study was to evaluate the effect and possible mechanism of hydrodynamics-based delivery of the IL-1 receptor antagonist (IL-1RA)-immunoglobulin (Ig) gene for treatment of rat experimental autoimmune myocarditis (EAM).Author: Hui Liu, Haruo Hanawa, Tsuyoshi Yoshida, Raafat Elnaggar, Manabu Hayashi, Ritsuo Watanabe, Ken Toba,...
https://www.hindawi.com/journals/bmri/2013/928790/
In this study, we examined the effect of various types of gene delivery carriers on enhancing the uptake and gene expression of exogenous DNA in murine hepatocytes when a hydrodynamics-based gene delivery (HGD) is performed via tail-vein injection.Author: Shingo Nakamura, Tadaaki Maehara, Satoshi Watanabe, Masayuki Ishihara, Masahiro Sato
https://www.sciencedirect.com/science/article/pii/S0065266005540045
Hydrodynamic delivery has emerged as a near‐perfect method for intracellular DNA delivery in vivo.For gene delivery to parenchymal cells, only essential DNA sequences need to be injected via a selected blood vessel, eliminating safety concerns associated with current viral and synthetic vectors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/
Aug 21, 2015 · Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided …Author: Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Yuji Kobayashi, Kohei Ogawa, Yoko Shinagawa, Ryosuke In...
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.200425776
In this study, we demonstrated that pCAGGS‐IL‐13‐Ig gene transfer on day 1 or day 7 by hydrodynamics‐based transfection enormously suppressed EAM in rats. It has been reported that gene delivery of recombinant IL‐13 or IL‐4 by using HSV‐1 vectors exerted a protective effect on the development of rat EAE 21, 22.Author: Raafat Elnaggar, Haruo Hanawa, Hui Liu, Tsuyoshi Yoshida, Manabu Hayashi, Ritsuo Watanabe, Satoru Ab...
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