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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064722/
Hydrodynamic delivery is one of non-viral methods developed originally for intracellular gene delivery but later found applicable to delivery of other macromolecules such as oligo nucleotides, RNA, proteins, and the compounds that are not permeable to cell membrane.Author: Barbara Bonamassa, Li Hai, Dexi Liu
https://www.sciencedirect.com/science/article/pii/S1525001616327198
Hydrodynamic gene delivery uses a hydrodynamic force generated by a pressurized injection of a large volume of DNA solution into the blood vessel so as to permeabilize the capillary endothelium and generate “pores” in the plasma membrane of the surrounding parenchyma cells, through which DNA or other macromolecules of interest may reach the cell interior. 35, 36, 37 With time, the membrane …Author: Takeshi Suda, Dexi Liu
https://www.ncbi.nlm.nih.gov/pubmed/17912237
Recently, hydrodynamic gene delivery using a rapid injection of a relatively large volume of DNA solution has opened up a new avenue for gene therapy studies in vivo. This method is superior to the existing delivery systems because of its simplicity, efficiency, and versatility.Author: Takeshi Suda, Dexi Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/
Aug 21, 2015 · Hydrodynamics-based delivery utilizes hydrodynamic pressure induced by the volume and flow of injection as the driving force to facilitate intracellular gene transfer [1,2]. The original method of hydrodynamic gene delivery (HGD) in small animals involves tail vein injection of plasmid DNA solution in a volume equal to 8%–10% of the body weight (BW) in 5–7 s [ 1 , 3 ].Author: Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Yuji Kobayashi, Kohei Ogawa, Yoko Shinagawa, Ryosuke In...
https://www.sciencedirect.com/science/article/pii/S0065266005540045
Hydrodynamic delivery has emerged as a near‐perfect method for intracellular DNA delivery in vivo. For gene delivery to parenchymal cells, only essential DNA sequences need to be injected via a selected blood vessel, eliminating safety concerns associated with current viral and synthetic vectors.
https://www.researchgate.net/publication/315638224_Hydrodynamic_gene_delivery
Hydrodynamic gene delivery of Kringle-5 domain of plasminogen suppresses lung metastasis in mouse re...
https://www.frontiersin.org/articles/10.3389/fphar.2017.00591/full
Aug 30, 2017 · Over the past few years, hydrodynamic gene delivery (HGD) with naked DNA has drawn increasing interest in both research and potential clinic applications due to its high efficiency and low risk in triggering immune responses and carcinogenesis in comparison to viral vectors.Author: Mei Huang, Rui Sun, Qiang Huang, Zhigang Tian
https://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.3150
Hydrodynamic limb vein injection is an in vivo locoregional gene delivery method. It consists of administrating a large volume of solution containing nucleic acid constructs in a limb with both blood inflow and outflow temporarily blocked using a tourniquet. The fast, high pressure delivery allows the musculature of the whole limb to be reached.
https://onlinelibrary.wiley.com/doi/book/10.1002/3527607536
Aug 25, 2005 · As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867405/
Several physical methods were developed for gene delivery in vivo, among which hydrodynamic injection (HI), which represents a rapid injection of a large volume of DNA through the tail vein, was the simplest and highly effective method (10, 11).Author: Xiumei Li, Guangze Liu, Meijuan Chen, Yang Yang, Yong Xie, Xiangping Kong
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