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https://www.researchgate.net/publication/7512849_Hyaluronan_Pharmaceutical_Characterization_and_Drug_Delivery
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https://www.tandfonline.com/doi/abs/10.1080/10717540590952555
Oct 10, 2008 · The unique viscoelastic nature of hyaluronan along with its biocompatibility and nonimmunogenicity has led to its use in a number of cosmetic, medical, and pharmaceutical applications. More recently, HA has been investigated as a drug delivery agent for ophthalmic, nasal, pulmonary, parenteral, and dermal routes.Author: Yong-Hong Liao, Stuart A. Jones, Ben Forbes, Gary P. Martin, Marc B. Brown
https://www.tandfonline.com/doi/abs/10.1080/10717540590952555?needAccess=true
Hyaluronic acid (HA), is a polyanionic polysaccharide that consists of N-acetyl-D-glucosamine and β-glucoronic acid. It is most frequently referred to as hyaluronan because it exists in vivo as a p...Author: Yong-Hong Liao, Stuart A. Jones, Ben Forbes, Gary P. Martin, Marc B. Brown
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690785/
Apr 21, 2009 · Solid tumors have several potential barriers to drug delivery that may limit drug penetration, such as alterations in the distribution of blood vessels, blood flow, and interstitial pressure (34,35). Therefore, high systemic levels of the cytotoxic drug often cause a related systemic toxicity without reaching the tumor at effective concentrations.Author: Abeer M. Al-Ghananeem, Ahmad H. Malkawi, Yahya M. Muammer, Justin M. Balko, Esther P. Black, Walid M...
https://www.sciencedirect.com/science/article/pii/S0169409X19301425
These aspects are limit for a large use of HA as drug delivery system and require an improve tumor active targeting to improve the efficacy of HA as drug delivery system. The preliminary data from clinical trials indicate that the industrialization and wide clinical application of HA as drug delivery system are still to be properly developed. 6.Author: Alberto Passi, Davide Vigetti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468323/
Management of ovarian cancer still requires improvements in therapeutic options. A drug delivery strategy was tested that allows specific targeting of tumor cells in combination with a controlled release of a cytotoxic molecule. To this aim, the efficacy ...Author: Isabella Monia Montagner, Anna Merlo, Debora Carpanese, Gaia Zuccolotto, Davide Renier, Monica Campi...
https://pubs.acs.org/doi/10.1021/cr941199z
Cationic Conjugated Polymer/Hyaluronan-Doxorubicin Complex for Sensitive Fluorescence Detection of Hyaluronidase and Tumor-Targeting Drug Delivery and Imaging. ACS Applied Materials & Interfaces 2015, 7 (38) , 21529-21537. DOI: 10.1021/acsami.5b06799.Author: Lubomír Lapčík, Stefaan De Smedt, Joseph Demeester, Peter Chabreček
https://www.sciencedirect.com/science/article/pii/S0144861716310670
Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery.Author: Daniela Šmejkalová, Tomáš Muthný, Kristina Nešporová, Martina Hermannová, Eva Achbergerová, Gloria H...
https://www.researchgate.net/publication/280032376_Drug_conjugation_to_hyaluronan_widens_therapeutic_indications_for_ovarian_cancer
Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer. ... Drug conjugation to hyaluronan widens therapeutic indications ... pharmaceutical characterization and drug ...
http://pubs.acs.org/doi/abs/10.1021/cr941199z
His current research interests include the study of the action mechanism of different polymer-degrading pharmaceutical enzymes such as hyaluronidases, proteases, and cellulases, the characterization of polymers such as hyaluronates and proteoglycans, and the controlled delivery of macromolecular drugs using biodegradable polymer hydrogels ...
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