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https://stm.sciencemag.org/content/2/15/15ps3.full
Jan 20, 2010 · Drugs that block angiogenesis are important components of first-line therapies for a number of human cancers. However, some of these agents have undesirable effects on the patient. Optimal delivery systems must be developed to maximize clinical benefits and minimize adverse effects in cancer patients.Author: Yihai Cao, Robert Langer
https://stm.sciencemag.org/content/scitransmed/2/15/15ps3.full.pdf
Drugs that block angiogenesis are important components of fi rst-line therapies for a number of human cancers. However, some of these agents have undesirable eff ects on the patient. Optimal delivery systems must be developed to maximize clinical benefi ts and minimize adverse eff ects …Author: Yihai Cao, Robert Langer
https://www.researchgate.net/publication/43049765_Optimizing_the_Delivery_of_Cancer_Drugs_That_Block_Angiogenesis
Drugs that block angiogenesis are important components of first-line therapies for a number of human cancers. However, some of these agents have undesirable effects on the patient.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753668/
In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the addition of an anti-angiogenic component to conventional therapeutic modalities has generally produced modest survival benefits for cancer patients.Author: Yihai Cao, Yihai Cao, Yihai Cao
https://stm.sciencemag.org/content/2/15.toc
Oct 25, 2019 · Drugs that block new blood vessel formation—angiogenesis—are components of first-line therapies for a number of human cancers. However, antiangiogenic therapy can have undesirable effects on the patient, including rapid-rebound revascularization of tumors after withdrawal of the drug.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787308/
To elucidate the effects of angiogenesis inhibitors on drug delivery, a recent study used PET to investigate bevacizumab combined with (11 C)docetaxel in NSCLC patients. Bevacizumab reduced perfusion and the net influx rate of docetaxel, shortly after its administration, and for several days afterward, showing no substantial improvement in drug delivery into tumors.Author: Marta Cesca, Francesca Bizzaro, Massimo Zucchetti, Raffaella Giavazzi
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